Features and Functions of Human Microglia Cells

  • Fulvia Gremo
  • Valeria Sogos
  • Maria Grazia Ennas
  • Alessandra Meloni
  • Tiziana Persichini
  • Marco Colasanti
  • Giuliana Maria Lauro
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 429)

Abstract

Microglia represent a population of resident cells of the central nervous system (CNS) which have attracted much interest because of their multiple functions. Two principal forms of microglia have been described. “Ameboid” cells, also referred as gitter cells or reactive microglia, which appear during the embryonal period and after brain lesions, are morphologically similar to macrophages (Giulian and Baker, 1986; Giulian, 1987). The second form of microglia, the “ramified” cells (Ling, 1981), appear during the late postnatal period and persist through adult life (Murabe and Sano, 1983). Although the nature of the relationship between ameboid and ramified microglia is controversial, ramified microglia are generally viewed as functional quiescent microglia that lack monocytic properties, but acquire ameboid features and reactivity in the presence of tissue damage (del Rio Hortega, 1919; 1932; Oemichen, 1983).

Keywords

Microglia Cell Platelet Activate Factor Basic Fibroblast Growth Factor High Affinity Site Human Fetal Brain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Fulvia Gremo
    • 1
    • 2
  • Valeria Sogos
    • 1
    • 2
  • Maria Grazia Ennas
    • 1
    • 2
  • Alessandra Meloni
    • 1
    • 2
  • Tiziana Persichini
    • 1
    • 2
  • Marco Colasanti
    • 1
    • 2
  • Giuliana Maria Lauro
    • 1
    • 2
  1. 1.Department of CytomorphologySchool of MedicineCagliariItaly
  2. 2.Department of Cell BiologyIII UniversityRomaItaly

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