Efficacy of Prophylactic and Therapeutic Administration of Antitoxin for Inhalation Botulism

  • David R. Franz
  • Louise M. Pitt
  • Michael A. Clayton
  • Martha A. Hanes
  • Kenneth J. Rose


Botulism is caused by intoxication with one or more of the seven neurotoxins produced by Clostridium botulinum. Food poisoning is the most common cause of botulism. Accidental inhalation exposure, however, has been reported in the laboratory,4 and inhalation is the likely route of exposure after the toxin’s use as a terrorist weapon or warfare agent. Toxoids are available for immunization, but there are presently no known drugs that can be used to prevent or treat botulinum intoxication. A pentavalent human, hyperimmune globulin product6 and a heptavalent, equine F(ab’)2 (despeciated) antitoxin (unpublished data, G.E. Lewis, Jr. and R.M. Condie) were evaluated in a preliminary study as prophylaxis or therapy for inhalation botulism (serotype A) in rhesus monkeys.


Botulinum Toxin Minute Volume Clostridium Botulinum Mouth Breathing Aerosol Challenge 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • David R. Franz
    • 1
  • Louise M. Pitt
    • 1
  • Michael A. Clayton
    • 1
  • Martha A. Hanes
    • 2
  • Kenneth J. Rose
    • 3
  1. 1.Toxinology Divisions U.S. Army Medical Research Institute of Infectious DiseasesFort DetrickFrederickUSA
  2. 2.Pathology Divisions U.S. Army Medical Research Institute of Infectious DiseasesFort DetrickFrederickUSA
  3. 3.Veterinary Medicine Divisions U.S. Army Medical Research Institute of Infectious DiseasesFort DetrickFrederickUSA

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