Tetanus Toxin as a Tool for Investigating the Structural Bases of Neurotropism

  • Bernard Bizzini
  • Mohamed Khiri
  • Martine Carlotti


Tetanus toxin binds with high affinity to fixation sites at the nerve terminal membrane. As a result the toxin molecule is internalized and transported retrogradely within the axon to the central nervous system (CNS). This neurotoxin is a “neurotropic” agent, since it is endowed with the capacity to migrate selectively to the CNS.


Nerve Growth Factor Rabies Virus Wheat Germ Agglutinin Retrograde Transport Tetanus Toxin 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Bernard Bizzini
    • 1
  • Mohamed Khiri
    • 1
  • Martine Carlotti
    • 1
  1. 1.Department of Molecular ToxinologyPasteur InstituteParis CedexFrance

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