Abstract
Botulinum neurotoxins comprise a class of potent inhibitors of neurotransmitter release, thus acting presynaptically. Their function has been biochemically dissected into distinct stages: i) cell surface attachment; ii) internalization via the endocytotic/lysosomal vesicle pathway; iii) penetration into the cytoplasm from these vesicles through a pH-dependent conformational change; and iv) intracellular poisoning.1 There are seven distinct serotypes, some of which have been sequenced.2
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References
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© 1993 Springer Science+Business Media New York
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Schmid, M.F., Robinson, J.P., DasGupta, B.R. (1993). Structure of Botulinum Neurotoxin Channels in Phospholipid Vesicles. In: DasGupta, B.R. (eds) Botulinum and Tetanus Neurotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9542-4_43
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DOI: https://doi.org/10.1007/978-1-4757-9542-4_43
Publisher Name: Springer, Boston, MA
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