Structure of Botulinum Neurotoxin Channels in Phospholipid Vesicles

  • M. F. Schmid
  • J. P. Robinson
  • B. R. DasGupta


Botulinum neurotoxins comprise a class of potent inhibitors of neurotransmitter release, thus acting presynaptically. Their function has been biochemically dissected into distinct stages: i) cell surface attachment; ii) internalization via the endocytotic/lysosomal vesicle pathway; iii) penetration into the cytoplasm from these vesicles through a pH-dependent conformational change; and iv) intracellular poisoning.1 There are seven distinct serotypes, some of which have been sequenced.2


Vesicle Wall Botulinum Neurotoxin Tetanus Toxin Clostridium Botulinum Distinct Serotypes 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • M. F. Schmid
    • 1
  • J. P. Robinson
    • 1
  • B. R. DasGupta
    • 2
  1. 1.Verna and Marrs McLean Department of BiochemistryBaylor College of MedicineHoustonUSA
  2. 2.Department of Food Microbiology and ToxicologyUniversity of Wisconsin-MadisonMadisonUSA

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