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Botulinum and Tetanus Neurotoxins pp 25–29Cite as

Therapeutic Potential of Neurotrophic Factors: The Role of Ciliary Neurotrophic Factor in Promoting Neuronal Survival and Recovery Following Neuronal Injury

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Abstract

Neurotrophic factors are naturally occurring proteins that promote the survival and functional activities of nerve cells.1 Traditionally, neurotrophic factors were found in the target cell to which an innervating nerve cell connects. Such target-derived neurotrophic factors regulate the number of contacts formed between the innervating nerve cells and the target cell population.’ Since the innervating nerve cells are dependent for their survival on the target-derived neurotrophic factor and since their access to the factor is limited, the levels of available factor influence both the survival of nerve cells and the development of synaptic connections.2

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Author information

Authors and Affiliations

  1. Synergen Inc., Boulder, Colorado, 80301, USA

    James L. McManaman, Deborah Russell & Frank Collins

Authors
  1. James L. McManaman
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  2. Deborah Russell
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  3. Frank Collins
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Editor information

Editors and Affiliations

  1. University of Wisconsin, Madison, Wisconsin, USA

    Bibhuti R. DasGupta

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© 1993 Springer Science+Business Media New York

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McManaman, J.L., Russell, D., Collins, F. (1993). Therapeutic Potential of Neurotrophic Factors: The Role of Ciliary Neurotrophic Factor in Promoting Neuronal Survival and Recovery Following Neuronal Injury. In: DasGupta, B.R. (eds) Botulinum and Tetanus Neurotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9542-4_4

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  • DOI: https://doi.org/10.1007/978-1-4757-9542-4_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9544-8

  • Online ISBN: 978-1-4757-9542-4

  • eBook Packages: Springer Book Archive

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