Thoughts on Action of Botulinum Toxin Suggested by Reversibility of Heart Effects

  • Carl Lamanna


Botulinum neurotoxin poisoning prevents the release of the neurotransmitter acetylcholine into the synaptic cleft. Stimulation of the cholinergic nerve is required for the acetylcholine-containing vesicles to attach to the inner surface at specific points of the nerve cell synaptic membrane. Thereupon at these points of attachment the acetylcholine leaves the vesicles to escape into the synaptic cleft by passage across the synaptic membrane. This event has been called exocytosis and is probably the action frustrated by the presence of toxin.


Synaptic Cleft Synaptic Membrane Cholinergic Nerve Isolate Heart Preparation Tetanus Neurotoxin 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Carl Lamanna
    • 1
  1. 1.Carolina Meadows V267Chapel HillUSA

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