Thoughts on Action of Botulinum Toxin Suggested by Reversibility of Heart Effects
Botulinum neurotoxin poisoning prevents the release of the neurotransmitter acetylcholine into the synaptic cleft. Stimulation of the cholinergic nerve is required for the acetylcholine-containing vesicles to attach to the inner surface at specific points of the nerve cell synaptic membrane. Thereupon at these points of attachment the acetylcholine leaves the vesicles to escape into the synaptic cleft by passage across the synaptic membrane. This event has been called exocytosis and is probably the action frustrated by the presence of toxin.
KeywordsSynaptic Cleft Synaptic Membrane Cholinergic Nerve Isolate Heart Preparation Tetanus Neurotoxin
Unable to display preview. Download preview PDF.
- 1.Duchen LW, Strich SJ. The effects of botulinum toxin on the pattern of innervation of skeletal muscle in the mouse. Quart J Exp Physiol Cogn Med Sci 1968; 53: 84–89.Google Scholar
- 2.Lamanna C. Overview of bacterial toxins with a nonreductionist approach to the mode of action of botulinal neurotoxin. In: Pohland AE et al., eds. Microbial toxins in foods and feeds. New York: Plenum Press, 1990.Google Scholar
- 3.Lamanna C, El-Hage AN, Vick JA. Cardiac effects of botulinal toxin. Arch Int Pharmacodyn Therap 1988; 293: 69–83.Google Scholar