Classic studies on nerve growth factor (NGF) revealed its essential role as a survival and differentiation factor in both the peripheral and central nervous systems (Levi-Montalcini, 1987; Thoenen et al., 1987). The biological actions of NGF include survival of embryonic and adult neurons and induction of neurite outgrowth and neurotransmitter enzymes. The primary targets in the peripheral nervous system are sympathetic and populations of sensory neurons derived from the neural crest. In the central nervous system, NGF is capable of influencing cholinergic neurons in the basal forebrain by the induction of choline acetyltransferase (ChAT) activity (Mobley et al., 1985; Martinez et al., 1985), and by reducing, or even preventing degeneration of basal forebrain neurons. A number of differentiative properties are induced by NGF, including increased tyrosine hydroxylase, acetylcholinesterase, and choline acetyltransferase activities, as well as many neuron specific proteins such as synapsin, tau, microtubule associated proteins, neurofilaments, and sodium channels (Chao, 1990).
KeywordsPC12 Cell Nerve Growth Factor Papillary Thyroid Carcinoma Nerve Growth Factor Receptor Affinity Crosslinking
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