Tetanus Neurotoxin: (1) Immunological Roles of Fragments of the Toxin in Protection, and (2) Attempts to Identify Target Site(s) of Its Toxic Action

  • Morihiro Matsuda
  • Toshio Okabe
  • Nakaba Sugimoto


We have been working on the structure-function relationship of tetanus neurotoxin, not only from a fundamental (biological) point of view, as a basis for understanding the mechanism of action of tetanus neurotoxin, but also from a practical (medical) point of view, as a basis for improvement of prophylaxis and treatment of tetanus.


Phorbol Myristate Acetate Chromaffin Cell Phorbol Myristate Acetate Tetanus Toxin Plasma Membrane Vesicle 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Morihiro Matsuda
    • 1
  • Toshio Okabe
    • 1
  • Nakaba Sugimoto
    • 1
  1. 1.Department of Tuberculosis Research (Bacterial Toxinology) Research Institute for Microbiol DiseasesOsaka UniversityOsaka, 565Japan

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