Endosome Processing: Structural, Functional and Kinetic Interrelations

  • Lutz Thilo


Clostridial neurotoxins exert their effect from within the cytoplasm of nerve cells. Rather than gaining direct access through the cell-surface membrane, the toxin exploits the process of endocytosis to gain entry into cells. As this would still leave the toxin on the exoplasmic side of the endocytic membrane, a translocation step through the membrane into the cytoplasm must follow at some stage along the endocytic pathway. An awareness of the steps which are involved in endosome processing can be helpful to assess the mechanism by which the toxin can reach its site of action in the cell.


Early Endosome Late Endosome Endocytic Pathway Endocytic Vesicle Membrane Constituent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Lutz Thilo
    • 1
  1. 1.Dept. of Medical BiochemistryUniversity of Cape Town Medical SchoolObservatory, Cape TownSouth Africa

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