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RH Blood Groups and Rh-Deficiency Syndrome

  • Jean-Pierre Cartron
  • Peter Agre
Chapter
Part of the Blood Cell Biochemistry book series (BLBI, volume 6)

Abstract

The discovery of the RH blood group system by Levine and his colleagues (1939, 1941a, b) was associated with the historical description of a fetomaternal alloimmunization responsible for the hemolytic disease of the newborn. The intrauterine fetal death was caused by a maternal antibody directed against an antigen on the surface of her infant’s red cells which was inherited from the father. This antibody had crossed the placenta and destroyed the fetal red cells.

Keywords

Blood Group Blood Group Antigen Membrane Skeleton Blood Group System Antipeptide Antibody 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Jean-Pierre Cartron
    • 1
  • Peter Agre
    • 2
  1. 1.Unité de Recherche U76 de l’Institut National de la Santé et de la Recherche Médicale (INSERM)Institut National de la Transfusion SanguineParisFrance
  2. 2.Departments of Medicine and Cell Biology/AnatomyJohns Hopkins University School of MedicineBaltimoreUSA

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