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Molecular Basis of Human Blood Group Antigens pp 397–419Cite as

Blood Group Antigens as Markers of Complement and Complement Regulatory Molecules

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Part of the book series: Blood Cell Biochemistry ((BLBI,volume 6))

Abstract

Complement is a complex system of about 20 interacting proteins which, by means of a cascade of proteolytic reactions, create fatal lesions in the membranes of microorganisms. Fragments released during complement activation attract phagocytes to the site of infection and facilitate phagocytosis. Complement receptors on phagocytes and red cells bind to the complement within immune complexes so as to expedite their removal from the circulation. Complement can be activated by the classical or alternative pathways, the former generally requiring the presence of antibody and the latter often being triggered directly by a foreign particle in the absence of antibody. For reviews on complement see Porter (1983) and Law and Reid (1988).

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  1. Medical Research Council Blood Group Unit, London , NW1 2HE, UK

    Geoff Daniels

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  1. National Institute of Blood Transfusion, Paris, France

    Jean-Pierre Cartron  & Philippe Rouger  & 

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Daniels, G. (1995). Blood Group Antigens as Markers of Complement and Complement Regulatory Molecules. In: Cartron, JP., Rouger, P. (eds) Molecular Basis of Human Blood Group Antigens. Blood Cell Biochemistry, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9537-0_15

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