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Gerbich Blood Groups and Minor Glycophorins

  • Chapter
Molecular Basis of Human Blood Group Antigens

Part of the book series: Blood Cell Biochemistry ((BLBI,volume 6))

Abstract

The group of red cell membrane glycoproteins known as glycophorins, in reference to their high carbohydrate content (Marchesi et al., 1972), have been used for years as a general model to probe the structure and function of membrane proteins and as specific markers of erythroid differentiation (for reviews, see Bretscher, 1973; Steck, 1974; Marchesi et al., 1976; Wise, 1984). It has been suggested that the large quantity of sialic acids carried by these glycoproteins confers on the red cells a strong negative charge that keeps the erythrocytes apart from each other (Bretscher, 1973). They may in addition serve as ligands for viruses, bacteria, and parasites (for reviews, see Burness, 1981; Hadley et al., 1986; Gahmberg et al.,1988).

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Authors and Affiliations

  1. Unité de Recherche U76 de l’Institut National de la Santéet de la Recherche Médicale (INSERM), Institut National de la Transfusion Sanguine, Paris, 75015, France

    Yves Colin & Caroline Le Van Kim

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  1. Yves Colin
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  1. National Institute of Blood Transfusion, Paris, France

    Jean-Pierre Cartron  & Philippe Rouger  & 

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Colin, Y., Van Kim, C.L. (1995). Gerbich Blood Groups and Minor Glycophorins. In: Cartron, JP., Rouger, P. (eds) Molecular Basis of Human Blood Group Antigens. Blood Cell Biochemistry, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9537-0_12

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