Gerbich Blood Groups and Minor Glycophorins

  • Yves Colin
  • Caroline Le Van Kim
Part of the Blood Cell Biochemistry book series (BLBI, volume 6)

Abstract

The group of red cell membrane glycoproteins known as glycophorins, in reference to their high carbohydrate content (Marchesi et al., 1972), have been used for years as a general model to probe the structure and function of membrane proteins and as specific markers of erythroid differentiation (for reviews, see Bretscher, 1973; Steck, 1974; Marchesi et al., 1976; Wise, 1984). It has been suggested that the large quantity of sialic acids carried by these glycoproteins confers on the red cells a strong negative charge that keeps the erythrocytes apart from each other (Bretscher, 1973). They may in addition serve as ligands for viruses, bacteria, and parasites (for reviews, see Burness, 1981; Hadley et al., 1986; Gahmberg et al.,1988).

Keywords

Human Erythrocyte Blood Group Antigen Human Erythrocyte Membrane Hereditary Elliptocytosis Nonerythroid Cell 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Yves Colin
    • 1
  • Caroline Le Van Kim
    • 1
  1. 1.Unité de Recherche U76 de l’Institut National de la Santéet de la Recherche Médicale (INSERM)Institut National de la Transfusion Sanguine ParisFrance

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