Lutheran Antigens, Lutheran Regulatory Genes, and Lutheran Regulatory Gene Targets

  • Neeraja Rao
  • Marilyn J. Telen
Part of the Blood Cell Biochemistry book series (BLBI, volume 6)


The Lutheran blood group is a family of red cell polymorphisms comprising at least two major alleles, Lu a and Lu b. Lutheran antigens are for the most part clinically insignificant, although some Lutheran antibodies cause mild clinical problems. Nevertheless, the Lutheran blood group antigens have played an important role in the study of human genetics, and further research of Lutheran regulatory genes promises to be equally informative. The genetic importance of the Lutheran system first came to light when Jan Mohr (1951, 1954) demonstrated that the Lutheran locus (Lu) and the Secretor locus (Se) provided the first known example of autosomal crossing-over and then suggested a further linkage between the myotonic dystrophy gene (DM) and the Lu and Se loci. Furthermore, it was the Lu-Se linkage that gave the first evidence that the frequency of crossing-over was sex-related (Cook, 1965). The linkage between the Lu and Dm genes was later proven (Renwick et al., 1971). Since these findings, Lu has been mapped to chromosome 19 by genetic linkage to the third component of human complement (C3) (Eiberg et al., 1983). Evidence that Se is distal to Lu on chromosome 19q has been provided by Zelinski et al. (1989).


Blood Group Autoimmune Hemolytic Anemia Blood Group Antigen Blood Group System Lymphocyte Homing 
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© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Neeraja Rao
    • 1
  • Marilyn J. Telen
    • 1
  1. 1.Department of Medicine, Division of Hematology/OncologyDuke University Medical CenterDurhamUSA

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