Complement Receptors

  • S. K. Alex Law
Part of the Blood Cell Biochemistry book series (BLBI, volume 5)


Complement was first described as a heat-labile component in serum with bactericidal activity. It was subsequently found to also participate in many aspects of host defense against infection, including the initiation of inflammation, opsonization of microorganisms, and regulation of the immune response. To date, most, if not all, of the serum proteins that constitute the complement system have been identified and their activities characterized. Three types of interactions may be described for the complement proteins: (i) with each other, resulting in the sequential activation of the complement components in a cascade manner as well as in the regulation of such activation; (ii) with surface components of target cells, leading to their opsonization by the covalent binding of activated C3 and C4 fragments, and their cytolysis by the insertion of the terminal complex into the membrane; and (iii) with receptors on cells and tissues to bring about various immunologic responses. In this chapter, the structure and function of the complement receptors on the macrophage and related cells are described.


Phorbol Ester Complement Receptor Human Complement Membrane Cofactor Protein Lung Surfactant Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • S. K. Alex Law
    • 1
  1. 1.The MRC Immunochemistry Unit, Department of BiochemistryUniversity of OxfordOxfordUK

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