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Electrophysiology of Osteoclasts and Macrophages

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Part of the Blood Cell Biochemistry book series (BLBI,volume 5)

Abstract

Membrane potential and ionic conductances play a role in regulating many cell functions. In macrophages, it has been suggested that ionic currents participate in transmembrane signaling, phagocytosis, secretion, and motility (Ince et al., 1988; Riches et al., 1988; Gallin, 1991). Macrophages have been shown to possess several different types of K+ and Cl-channels. Osteoclasts, which are specialized cells responsible for resorption of mineralized tissues, have a number of different plasma membrane ion transporters, including a proton ATPase, as well as K+ and Cl-channels. These ion channels and transporters are thought to be involved in the process and regulation of H+ transport, and hence bone resorption (Vaes, 1988; Blair et al., 1989, 1991; Hall, 1991; Sims et al.,1992).

Keywords

  • Membrane Potential
  • Outward Current
  • Mouse Peritoneal Macrophage
  • Pump Current
  • Disulfonic Acid

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Dixon, S.J., Arkett, S.A., Sims, S.M. (1993). Electrophysiology of Osteoclasts and Macrophages. In: Horton, M.A. (eds) Macrophages and Related Cells. Blood Cell Biochemistry, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9534-9_8

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