Antigens of Osteoclasts Phenotypic Definition of a Specialized Hemopoietic Cell Lineage

  • M. H. Helfrich
  • M. A. Horton
Part of the Blood Cell Biochemistry book series (BLBI, volume 5)


Immunological approaches have readily found a place in the analysis of hemopoietic differentiation and led to the definition of cellular subpopulations which previously had only been identified by applying functional criteria. Increasingly, the techniques of monoclonal antibody technology, biochemical analysis, and, more recently, molecular cloning have been applied to questions of bone cell biology. In this chapter we review the current literature on the expression of antibody-defined antigens of osteoclasts, bone-resorbing cells of hemopoietic origin. The definition of the immunophenotype of human osteoclasts is considered primarily, but, where relevant, features of avian and rodent cells are also discussed. Our knowledge of the function of the majority of osteoclast antigens is limited; we do, however, speculate about a role in bone for some molecules, for example, aminopeptidase N (CD13), CD9, ICAM-1 (CD54), and the transferrin receptor (CD71). A section on adhesive molecules, mainly integrins, is included as they were among the first “specific” markers of human osteoclasts to be reported (the vitronectin receptor, CD51, by Horton et al., 1985a) and the definition of their functional activity in osteoclasts is well advanced. Finally, we review the application of immunological techniques to the phenotypic analysis of cells of the mononuclear phagocyte system and compare their characteristics with those of osteoclasts, particularly as there has been considerable dispute over their exact interrelationship.


Bone Resorption Giant Cell Giant Cell Tumor Mononuclear Phagocyte System Hemopoietic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • M. H. Helfrich
    • 1
  • M. A. Horton
    • 1
  1. 1.Imperial Cancer Research Fund Haemopoiesis Research Group, Department of HaematologySt. Bartholomew’s HospitalLondonUK

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