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Macrophages and Prostaglandins

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Part of the Blood Cell Biochemistry book series (BLBI,volume 5)

Abstract

Macrophages were originally considered merely to be scavenger cells whose function was to protect against invading microbes or eliminate unwanted debris from necrotic areas. However, it has become apparent from very many in vitro studies that monocytes/macrophages or mononuclear phagocytes can synthesize an enormous number of products, many of which are secreted from the cell (Nathan, 1987). It is clear that mononuclear phagocytes change their properties depending on, for example, the tissue and species of origin and on the agent(s) used both to elicit them into tissues and also to modulate their in vitro behavior. The word “activation” was originally applied to describe alterations in macrophage properties, such as enhanced bactericidal killing or spreading (Karnovsky and Lazdins, 1978). The “activation state” of a macrophage in most cases is probably a reflection both of the degree of differentiation (or maturation) of the cell as well as of the changes resulting from “immunologic events” occurring in vivo or in vitro.

Keywords

  • Arachidonic Acid
  • Alveolar Macrophage
  • Peritoneal Macrophage
  • Human Monocyte
  • Murine Macrophage

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© 1993 Springer Science+Business Media New York

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Hamilton, J.A. (1993). Macrophages and Prostaglandins. In: Horton, M.A. (eds) Macrophages and Related Cells. Blood Cell Biochemistry, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9534-9_5

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  • DOI: https://doi.org/10.1007/978-1-4757-9534-9_5

  • Publisher Name: Springer, Boston, MA

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