Origin of Macrophages

  • L. A. Ginsel
Part of the Blood Cell Biochemistry book series (BLBI, volume 5)


Macrophages are the mature elements of the mononuclear phagocyte system (MPS) (Langevoort et al., 1970; Van Furth et al., 1972). This system was developed as a result of severe criticism of the original concept of the reticuloendothelial system (Aschoff, 1924) and comprises all cells that show avid phagocytosis. The mononuclear phagocyte concept considers all macrophages to be the recent progeny of bone marrow-derived monocytes, which traverse the circulation en route to various sites of the body, where they are needed in host defense processes.


Kupffer Cell Mononuclear Phagocyte Resident Macrophage Mouse Peritoneal Macrophage Bone Marrow Culture 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • L. A. Ginsel
    • 1
    • 2
  1. 1.Laboratory for Electron MicroscopyUniversity of LeidenLeidenThe Netherlands
  2. 2.Department of Cell Biology and HistologyUniversity of NijmegenNijmegenThe Netherlands

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