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Macrophages and Related Cells pp 307–333Cite as

Leukocyte Integrins

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Part of the book series: Blood Cell Biochemistry ((BLBI,volume 5))

Abstract

Adhesion of macrophages to other cell types and to components of the extracellular matrix is essential for their immunomodulatory and effector functions. Cell surface receptors that mediate adherence can deliver signals within the cell that result in cellular activation and differentiation. Moreover, modulation of the function of cell surface receptors allows two-way communication across the plasma membrane. Thus, the macrophage is able to “sense” and respond appropriately to local environmental stimuli. Dialog between the cell and its local microenvironment is dynamic, made possible by regulation of the repertoire and function of adhesive receptors present on the macrophage surface. Three major families of cell surface molecules that have a role in cellular adhesion processes have been defined, namely, the immunoglobulin (Williams and Barclay, 1988), selectin (Stoolman, 1989), and integrin (Hynes, 1987) families. The subfamily of the integrins known as leukocyte integrins mediates a number of adhesive interactions of leukocytes that are pivotal to effective immune function (see Springer, 1990, for a recent review). These receptors were first identified as having roles in cell—cell contact and phagocytic responses of macrophages, and studies relating to their structure, function, and regulation continue to shed light on the molecular mechanisms of leukocyte adhesion processes.

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  1. Department of Respiratory Medicine, City Hospital, Edinburgh, EH10 5SB, UK

    Ian Dransfield

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  1. Imperial Cancer Research Fund Haemopoiesis Research Group, Department of Haematology, St. Bartholomew’s Hospital Medical College, EC1A 7BE, London, UK

    Michael A. Horton

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Dransfield, I. (1993). Leukocyte Integrins. In: Horton, M.A. (eds) Macrophages and Related Cells. Blood Cell Biochemistry, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9534-9_12

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