Subcellular Morphology and Biochemistry of Eosinophils

  • A. M. Dvorak
  • S. J. Ackerman
  • P. F. Weller
Part of the Blood Cell Biochemistry book series (BLBI, volume 2)


The purpose of this chapter is to illustrate the power of ultrastructural morphologic analysis either alone or combined with newer ultrastructural protocols in aiding our understanding of eosinophil biology. We draw from our personal knowledge of eosinophils from several species (human, mouse, guinea pig, rat, rabbit, opossum, and monkey) but most particularly from our ultrastructural studies of human eosinophils in vivo and in vitro. We first review general substructural features of mature eosinophils as a granulocyte class and then review the established morphologic rules for eosinophil differentiation and maturation by emphasizing the morphology of eosinophilic myelocytes in general. Included in this discussion is an overview of eosinophil granulogenesis. We also consider some key sources of confusion regarding eosinophil morphology and address particular criteria needed to avoid these potential pitfalls.


Lipid Body Bullous Pemphigoid Human Basophil Human Eosinophil Tissue Eosinophil 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • A. M. Dvorak
    • 1
  • S. J. Ackerman
    • 1
  • P. F. Weller
    • 1
  1. 1.Departments of Pathology and Medicine, Beth Israel Hospital and Harvard Medical School, and Charles A. Dana Research InstitutueBeth Israel HospitalBostonUSA

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