Megakaryocyte Maturation and Platelet Release in Normal and Pathologic Conditions

  • Janine Breton-Gorius
Part of the Blood Cell Biochemistry book series (BLBI, volume 2)


By examination of histological preparations, Wright (1906) was the first to suggest that platelets originate from fragmentation of the cytoplasm of bone marrow megakaryocytes. These cells can be differentiated from other bone marrow cells by their large size, which is related to the process of endomitosis leading to a polyploid nucleus (Levine et al., 1982).


Platelet Factor Megakaryoblastic Leukemia Alpha Granule Human Megakaryocyte Transient Myeloproliferative Disorder 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Janine Breton-Gorius
    • 1
  1. 1.Hospital Henri MondorUnité 91 INSERMCreteilFrance

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