• Ann M. Dvorak
Part of the Blood Cell Biochemistry book series (BLBI, volume 4)


Basophils and mast cells, two unique but closely related cells, have fascinated investigators since their original descriptions by Ehrlich (1877, 1879). We also succumbed to this fascination when we identified large numbers of basophils in skin lesions of guinea pigs that had been sensitized to antigen emulsified in incomplete Freund’s adjuvant and sampled for ultrastructural analysis within 1 to 2 weeks after skin testing—reactions we called cutaneous basophil hypersensitivity (CBH) to distinguish them from classical delayed hypersensitivity (DH) skin reactions (H. F. Dvorak, 1974; H. F. Dvorak et al., 1970). The study of basophil and mast cell biology has been a major part of our ultrastructural research efforts during the past 20 years.


Mast Cell Human Mast Cell Release Reaction Human Basophil Ultrastructural Morphology 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Ann M. Dvorak
    • 1
  1. 1.Beth Israel Hospital and Harvard Medical SchoolBostonUSA

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