Hylan Gel for Soft Tissue Augmentation

  • Nancy E. Larsen
  • Cynthia T. Pollak
  • Karen Reiner
  • Edward Leshchiner
  • Endre A. Balazs


Hylan, a hyaluronan derivative, was chemically crosslinked with divinyl sulfone to produce water insoluble, elastoviscous hylan gel slurries. The physical and biological properties of this gel slurry were examined by rheological and particle size analysis and by in vivo studies. Hylan gel slurries are made up of pseudoplastic, deformable gel particles with greater elasticity (at all frequencies) and greater viscosity (at low shear rate, e.g. 0.01 s−1) than the soluble hylan polymer.


Tissue Reaction Intradermal Injection Intercellular Matrix Soft Tissue Augmentation Divinyl Sulfone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Nancy E. Larsen
    • 1
  • Cynthia T. Pollak
    • 1
  • Karen Reiner
    • 1
  • Edward Leshchiner
    • 1
  • Endre A. Balazs
    • 1
  1. 1.Departments of Biochemistry, Histology and ChemistryBiomatrix, Inc.RidgefieldUSA

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