Abstract
A prodrug of 5-fluorouracil [5-FU] was prepared by reacting a 5-FU slurry with hexylisocyanate, in dioxane, at room temperature. The resulting solid, called HIFU, was purified and the release rates of 5-FU were determined, in distilled water, and compared against 5-FU using the gas dispersion tube technique previously described, at both room temperature and at 37°C. HIFU was studied in the form of a powder and as a monolithic dispersion in poly(caprolactone), The prodrug releases 5-FU very rapidly in the powdered form and both HIFU and 5-FU gave the typical monolithic release profiles, which were linear when plotted against the square root of time.
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Gebelein, C.G., Gardner, D., Ellis, T. (1994). The Controlled Release of a 5-Fluorouracil Prodrug from a Biodegradable Matrix. In: Gebelein, C.G., Carraher, C.E. (eds) Biotechnology and Bioactive Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9519-6_30
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DOI: https://doi.org/10.1007/978-1-4757-9519-6_30
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