Abstract
The use of a dsRNA, stabilized against hydrolysis by enzymes in primate serum, in the treatment of AIDS and tropical spastic paraparesis (TSP), is described. This compound, poly inosinic.polycytidylic acid, stabilized with a complex of polylysine and carboxymethylcellulose, (PolyICLC), was given i.m. to AIDS patients with and without Zidovudine (AZT). In TSP it was given alone, i.m. The drug was well-tolerated in both groups of patients. Side effects were mild, consisting of a mild myalgia and very slight fever. Some beneficial effects are described.
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© 1994 Springer Science+Business Media New York
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Levy, H., Salazar, A., Morales, J., Morgan, O.S.C. (1994). The Use of Polyiclc in the Treatment of AIDS. In: Gebelein, C.G., Carraher, C.E. (eds) Biotechnology and Bioactive Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9519-6_26
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DOI: https://doi.org/10.1007/978-1-4757-9519-6_26
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9521-9
Online ISBN: 978-1-4757-9519-6
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