Biodegradable Polymers for the Controlled Delivery of Vaccines

  • E. Schmitt
  • D. R. Flanagan
  • R. J. Linhardt


New methods for the efficient and effective administration of vaccines are required particularly with the advent of new synthetic subunit vaccines. This chapter describes the approaches of several research groups to administer vaccines using biodegradable polymer carriers. Delivery systems composed of synthetic poly[esters] and poly[iminocarbonates] and natural (crosslinked serum albumin) biodegradable polymers are described. The antibody levels in response to these systems are presented, and possible mechanisms responsible for the observed effects are discussed. The important questions that need to be answered before this technology can be successfully applied are also discussed.


Release Profile Biodegradable Polymer Release Kinetic Glycolic Acid Secondary Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • E. Schmitt
    • 1
    • 2
  • D. R. Flanagan
    • 1
    • 2
  • R. J. Linhardt
    • 1
    • 2
  1. 1.Division of PharmaceuticsUniversity of IowaIowa CityUSA
  2. 2.Division of Medicinal and Natural Products Chemistry College of PharmacyUniversity of IowaIowa CityUSA

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