Development of Polymeric Beta-Lactam Systems — Synthetic Study and Characterization

  • Malay Ghosh


Over the past 40 years beta-lactam derivatives have been extensively used by the physicians as one of the best antimicrobial agents. Beta-lactam chemistry is well developed, however, reports on polymers containing beta-lactam system is very rare in literature. This paper will describe our study on synthesis of new polymeric systems containing a variety of substituted beta-lactam moieties. Penicillin based polymeric systems are also prepared and will be reported. The characterization of the new monomers, polymers and the result of the in vitro release study will be described.


Methyl Glyoxalate Oxalyl Chloride Methyl Ester Hydrochloride Allyl Ester Anti Isomer 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Malay Ghosh
    • 1
  1. 1.Schering-Plough Research InstituteKenilworthUSA

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