Experiences With Collagen-Derived Biomaterials in Research and Treatment of Humans

  • A. Stemberger
  • R. Ascherl
  • M. A. Scherer
  • F. Bader
  • W. Erhardt
  • B. C. Adelmann-Grill
  • K. H. Sorg
  • H. P. Thomi
  • M. Stoltz
  • J. Jeckle
  • T. Seaber
  • G. Blümel

Abstract

Collagen derived biomaterials have been used in medicine for ages. Intact, native collagen fibrils can be prepared in high purity from bovine tendons by pepsin treatment. Formulation of foils and sponges by freeze-drying is an accepted procedure. In the body, collagen is resorbed by an active cellular mechanism. Porous collagen sponges serve as carriers for the fibrin adhesive system. In Germany, these materials are used to control bleeding in parenchymatic organs. A gentamicin-collagen compound is clinically used in bone and soft tissue infections.

Keywords

Soft Tissue Infection Drug Carrier System Septic Loosening Septic Surgery Bovine Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

  1. 1.
    G. V. R. Born, J. Physiol. Lond., 162 67–68 (1962). “Quantitative Investigations into Gengaggregation of Blood Platelets.”Google Scholar
  2. 2.
    A. Stemberger, R. Ascherl, F. Lechner, G. Blümel G, Eds, “Collagen as a Drug Carrier, Franklin Scientific (1991).Google Scholar
  3. 3.
    R. L. Trelstadt in: “Immunochemistry of the Extracellular Matrix, Vol I, Methods, H. Furthmayr, Ed, CRC Press, Boca-Raton, Florida, 1982, p. 32–39. “Native Collagen Fractionation”Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • A. Stemberger
    • 1
  • R. Ascherl
    • 1
  • M. A. Scherer
    • 1
  • F. Bader
    • 1
  • W. Erhardt
    • 1
  • B. C. Adelmann-Grill
    • 1
  • K. H. Sorg
    • 1
  • H. P. Thomi
    • 1
  • M. Stoltz
    • 1
  • J. Jeckle
    • 1
  • T. Seaber
    • 2
  • G. Blümel
    • 1
  1. 1.Institut für Experimentelle Chirurgie derTechnischen Universität MünchenMünchen 80Deutschland
  2. 2.Division of Orthopaedic SurgeryDuke University Medical CenterDurhamUSA

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