Cell Adhesive Properties of Bioelastic Materials Containing Cell Attachment Sequences

  • Alastair Nicol
  • D. Channe Gowda
  • Timothy M. Parker
  • Dan W. Urry


The biocompatibility, conformational and inverse temperature transition properties of poly(Vall-Pro2-Gly3-Va14- Gly5), i.e., poly(VPGVG), and its 7-irradiation crosslinked matrix and the poly(VPGVG)-derived hydrophobicity scale are noted. Also noted are the capacities of varying the bioactive role of bioelastic materials; that is, the bioelastic materials can be designed (1) to exhibit a range of elastic moduli, (2) to exhibit different rates of degradation, (3) for various modes of drug release, (4) to perform numerous free energy transductions, (5) to contain functional enzyme sites, and (6) to contain functional cell attachment sequences that promote growth to confluence.


Human Umbilical Vein Endothelial Cell Tissue Culture Plastic Bovine Aortic Endothelial Cell Human Fibronectin Vitronectin Receptor 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Alastair Nicol
    • 1
  • D. Channe Gowda
    • 1
  • Timothy M. Parker
    • 1
  • Dan W. Urry
    • 1
  1. 1.Laboratory of Molecular Biophysics School of MedicineThe University of Alabama at Birmingham, VH300BirminghamUSA

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