Hydrolytic Degradation of Poly DL-(Lactide)

  • N. S. Mason
  • C. S. Miles
  • R. E. Sparks
Part of the Polymer Science and Technology book series (POLS, volume 14)


Poly (DL-lactide) or poly (DL-lactic acid) (PLA), has been proposed as a component of several controlled-release drug forms because it degrades in living tissue to harmless products (1,2). Thus, devices or particles made of this material could be slowly metabolized and thus leave the body harmlessly after the drug is released. The solubility of PLA in many organic solvents (ketones, esters, aromatics, and chlorinated aliphatics) gives considerable flexibility in device fabrication. PLA has been proposed for use as fibers (3), microcapsules (4), and larger implants (2). Experimenters have made a variety of drug forms and devices to deliver drugs ranging from birth-control agents and narcotic antagonists, to anticoagulants and depressants.


Intrinsic Viscosity Hydrolytic Degradation Cyclic Dimer Narcotic Antagonist Large Implant 
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  1. 1.
    A. G. Boswell and R. E. Scribner, U.S. Patent 3,773, 919 (1973)Google Scholar
  2. 2.
    J. H. R. Woodland, S. Yolles, J. Med. Chem., 16, 897 (1973)CrossRefGoogle Scholar
  3. 3.
    R. J. Ruderman et al, Trans. A.S.A.I.O., XVIII 30 (1972)Google Scholar
  4. 4.
    L. R. Beck et al, Fertil. Steril., 31, 545 (1979)Google Scholar
  5. 5.
    C. Thies in “Microencapsulation”, T. Kondo ed., Techno, Inc., Tokyo (1979), p. 426Google Scholar
  6. 6.
    N. Mason, C. Thies, T. J. Cicero, J. Pharm. Sci., 65, 847 (1976)CrossRefGoogle Scholar
  7. 7.
    C. A. Bischoff, Chem. Ber., 26, 263 (1903)Google Scholar
  8. 8.
    W. H. Carothers et al, J. Am. Chem. Soc., 54, 761 (1932)CrossRefGoogle Scholar
  9. 9.
    A. K. Schneider, U.S. Patent 2,703, 316 (1955)Google Scholar
  10. 10.
    C. H. Holten et al, “Lactic Acid”, Verlag Chemie Weinheim, (1971), p. 232Google Scholar
  11. 11.
    D. D. Deane and E. G. Hammond, J. Dairy Sci., 43, 1421 (1960)CrossRefGoogle Scholar
  12. 12.
    J. Kleine and H. H. Kleine, Makromol. Chem., 30, 23 (1959)CrossRefGoogle Scholar
  13. 13.
    A. Schindler et al, “Biodegradable Polymers for Sustained Drug Delivery, Continuing Topics in Polymer Sci.”, Vol. II, Plenum 1977Google Scholar
  14. 14.
    R. K. Kulkarni et al, Arch. Surg., 93, 839 (1966)CrossRefGoogle Scholar
  15. 15.
    A. Seidel, “Solubilities of Organic Compounds” 3rd ed., D. Van Nostrand Co., Inc., New York (1941)Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • N. S. Mason
    • 1
  • C. S. Miles
    • 1
  • R. E. Sparks
    • 1
  1. 1.Department of Chemical EngineeringWashington UniversitySt. LouisUSA

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