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The Biochemical Properties of Carrier-Bound Methotrexate

  • John M. Whiteley
  • Barbara C. F. Chu
  • John Galivan
Chapter
Part of the Polymer Science and Technology book series (POLS, volume 14)

Abstract

From antiquity mankind has attempted to soothe ailments and control bodity functions with palliatives which usually on closer examination have contained some form of chemical compound. Examples include the use of laudanum and opiates for upset stomachs, the somewhat gross medieval use of leeches, which secrete fluids now known to contain heparin, to alleviate bloodflow problems, the discovery during the past century of the anesthetic properties of halogenated hydrocarbons, and the bacteriocidal properties of phenols, the more current usage of sulfonamides, tetracyclines, penicillins and other antibiotics, and presently the use of specific antimetabolites to control or quell aberrant enzymatic activity. Throughout this long period of development one can perceive the achievement of greater purity of the particular chemical compound or drug, greater understanding of its specific action, and a clearer delineation of the function it is being asked to perform.

Keywords

Lewis Lung Carcinoma Tumor Transplant BDF1 Mouse Halogenated Hydrocarbon L12l0 Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • John M. Whiteley
    • 1
  • Barbara C. F. Chu
    • 2
  • John Galivan
    • 3
  1. 1.Scripps Clinic and Research FoundationLa JollaUSA
  2. 2.Department of Medicine T-006University of CaliforniaSan DiegoUSA
  3. 3.Division of Laboratories and ResearchNew York State Department of HealthAlbanyUSA

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