Polythiosemicarbazides as Antimicrobial Polymers
Over a number of years, the antiparasitic and antibacterial properties of a large number of synthetic polymers have been examined by our research group. Among the materials examined were: sulfonamide-formaldehyde copolymers (1,2), sulfonamide-dimethylolurea copolymers (1,2), tropolone-formaldehyde copolymers (1,2), N-methacrylyl-l-aminoadamantane-methacrylic acid copolymers (1), and piperazine-dibasic acid copolymers (1). These materials have been tested against reasonably large numbers of parasite and bacterial species (1) in order to see if any structure-activity relationships could be observed. From this work it seemed that a number of potential structure-activity relationships could be noted (1). That is to say, observed activities apparently could be correlated with molecular weight, copolymer composition, and changes in substituents on the monomers from which the polymers were derived (1). Further, upon searching the literature, other polymer properties such as polyelectrolyte character, stereochemical configuration, crosslinking, etc. could be seen perhaps to exhibit trends toward being related to biological activities of various sorts (2). In addition, the molecular weight, copolymer composition, and substituent change presumed correlations which we observed in our own work also could be observed from independent results in the literature (2).
KeywordsVinyl Chloride Positive Bacterium Vinyl Alcohol Succinic Anhydride Copolymer Composition
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