Polymeric Drugs Containing 5-Fluorouracil and/or 6-Methylthiopurine. Chemotherapeutic Polymers. XI

  • Charles G. Gebelein
  • Richard M. Morgan
  • Robert Glowacky
  • Waris Baig
Chapter
Part of the Polymer Science and Technology book series (POLS, volume 14)

Abstract

The concept of polymeric drugs and their use in medication is much more recent than some of the other biomedical applications of polymers. In its simplest form, a polymeric drug is a polymer that contains a drug or chemotherapeutic unit as part of the polymer backbone, as a pendant group from the polymer chain or as a terminal group on the polymer chain. Hundreds of such compounds have been synthesized in the past few decades. In their more advanced forms, polymeric drugs could be complex copolymers of polymers attached to some natural substrate such as an imminoglobulin, a histone or a nucleic acid. Numerous reviews and books have appeared on this subject in the past decade (1–12). It would be beyond the scope of this present paper to attempt to review this rapidly developing field. We will concentrate primarily on polymers containing 5fluorouracil or 6-methylthiopurine and some closely related polymers. Prior to this, however, we will examine the basic concepts involved in polymeric drug medication.

Keywords

Pendant Group Acryloyl Chloride Directing Unit Control Release System Polymeric Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Charles G. Gebelein
    • 1
  • Richard M. Morgan
    • 1
  • Robert Glowacky
    • 1
  • Waris Baig
    • 1
  1. 1.Department of ChemistryYoungstown State UniversityYoungstownUSA

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