Abstract
We have been investigating the effect of chemical structure and surface properties of synthetic polymers on the coagulation of blood. The ultimate goal of these studies is the development of satisfactory prostheses to replace damaged veins, bypass obstructed arteries of small diameter (less than 6 mm) and for use in aortocoronary surgery. Currently, the surgeon is forced to use autogenous tissue such as the saphenous vein in these situations because of the lack of good synthetic polymer prostheses. Although the results using autogenous saphenous veins are very good, this method has certain disadvantages. Some patients (10 to 25%) do not have satisfactory veins either because of prior removal, disease (varicosities), or because the vein is of inadequate size. Even with patients having satisfactory veins, one has to contend with the problem of limited quantity and a significant increase in operating time. The presently available synthetic polymer prostheses are made from relatively thrombogenic polymers (Teflon and Dacron). These materials show patency rates of less than 50% at diameters smaller than 6 mm. Therefore, the development of a successful, small diameter synthetic polymer prosthesis is of utmost importance to both the patient and the surgeon.
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Reference
D. J. Lyman, L. C. Metcalf, D. Albo, Jr., D. F. Richards, and J. Lamb, Trans. Amer. Soc. Artif. Int. Organs, 20, 474 (1974)
E. W. Salzman, Fed. Proc. 30, 1503 (1971)
E. Nyilas, Proc. 23rd Ann. Conf. Eng. Med. Biol., 12, 147 (1970)
R. C. Dutton, R. E. Baier, R. L. Dedrick, and R. L. Bowman, Trans. Amer. Soc. Artif. Int. Organs, 14, 57 (1968)
R. E. Baier and R. C. Dutton, J -Biomed. Mat. Res., 3, 191 (1969)
H. Petscheck, D. Adams, and A. R. Kantrowitz, Trans. Amer. Soc. Artif. Int. Organs, 14, 256 (1968)
R. E. Baier, G. I. Loeb, and G. T. Wallace, Fed. Proc., 30, 1523 (1971)
A. J. Lande, L. Edwards, J. H. Bloch, R. G. Carlson, V. Subramanian, R. S. Ascheim, S. Scheidt, S. Fillmore, T. Killip, and C. W. Lillehei, Trans. Amer. Soc. Artif. Int. Organs, 16, 352 (1970)
D. J. Lyman, K. G. Klein, J. J. Brash, B. K. Fritzinger, J. D. Andrade, and F. S. Bonomo, Thromb. Diath. Haem. Suppl., 42, 109 (1971)
D. E. Scarborough, R. G. Mason, F. G. Dalldorf, and K. M. Brink-house, Lab. Invest., 20, 164 (1969)
D. J. Lyman, K. G. Klein, J. L. Brash, and B. K. Fritzinger, Thromb. Diathes. Haem., 23, 120 (1970)
M. A. Packham, G. Evans, M. F. Glynn, and J. F. Mustard, J. Lab. Clin. Med., 73, 686 (1969)
V. L. Gott and A. Furuse, Fed. Proc., 30, 1679 (1971)
D. S. P. Jenkins, M. A. Packham, M. A. Gucciore, and J. F. Mustard, J. Lab. Clin. Med., 81, 280 (1973)
J. F. Mustard, M. F. Glynn, E. E. Nishizawa, and M. A. Packham, Fed. Proc., 26, 106 (1967)
S. W. Kim and D. J. Lyman, App. Polymer Symp., 22, 189 (1973)
S. W. Kim, R. G. Lee, C. Adamson, and D. J. Lyman, Preprints Div. of Plastics and Organic Coatings, ACS, 165 36 (1973)
M. F. Glynn, M. A. Packham, J. Kirsh, and J. F. Mustard, J. Clin. Invest., 45, 1013 (1966)
M. B. Zucker and L. Vroman, Proc. Soc. Biol. Med., 131, 318 (1969)
D. J. Lyman and W. J. Seare, Jr., Ann. Revs. Maters. Sci., 4, 415 (1974)
D. J. Lyman, K. Knutson, B. McNeil, and K. Shibatani, Trans. Amer. Soc. Artif. Int. Organs, 21, 49 (1975)
D. J. Lyman, D. Albo, Jr., R. Jackson, and K. Knutson, Trans. Amer. Soc. Artif. Int. Organs, 23, 253 (1977)
D. J. Lyman, F. J. Fazzio, H. Voorhees, G. Robinsons, and D. A.bo, Jr., J. Biomed. Maters. Res., 12, 337 (1978)
D. J. Lyman, C. Kwan-Gett, H. J. Zwart, A. Bland, N. Eastwood, J. Kawai, and W. J. Kolff, Trans. Amer. Soc. Artif. Int. Organs, 17, 456 (1971)
D. E. Hokanson and E. E. Strandness, Surg. Gynecol. Obstet., 127 57 (1968)
E. R. Gozna, W. F. Mason, A. E. Marble, et al., Can. J. Surg., 15, 176 (1974)
W. V. Sharp and W. H. Falor, Am. J. Surg., 105, 802 (1963)
W. V. Sharp, A. F. Finelli, W. H. Falor, and J. W. Ferraro, Circulation, 29 (suppl.) 165 (1964)
W. V. Sharp, D. L. Gardner, and G. J. Andresen, Trans. Amer. Soc. Artif. Internal Organs, 11, 336 (1965)
B. Dreyer, T. Akutsu, and W. J. Kolff, J. Appl. Physiol., 15, 18 (1960)
V. Marinescu, E. Pausescu, and S. Carnaru, Thorax, 26, 108 (1971)
M. Wagner, G. Reul, J. Teresi, and K. L. Kayser, Am. J. Surg., 3, 838 (1966)
H. D. Berkowitz, L. J. Perloff, and B. Roberts, Surgery, 72, 888 (1972)
W. V. Sharp, D. L. Gardner, and G. J. Andresen, Trans. Amer. Soc. Artif. Int. Organs, 12, 179 (1966)
W. V. Sharp, D. L. Gardner, G. J. Andresen, and J. Wright, Trans. Amer. Soc. Artif. Int. Organs, 14, 73 (1968)
D. J. Lyman and R. H. Knowlton, Manuscript in preparation.
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Lyman, D.J., Seifert, K.B., Knowlton, H., Albo, D. (1981). Elastomeric Vascular Prostheses. In: Gebelein, C.G., Koblitz, F.F. (eds) Biomedical and Dental Applications of Polymers. Polymer Science and Technology, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9510-3_12
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