Elastomeric Vascular Prostheses

  • Donald J. Lyman
  • Kenneth B. Seifert
  • Helene Knowlton
  • Dominic AlboJr.
Chapter
Part of the Polymer Science and Technology book series (POLS, volume 14)

Abstract

We have been investigating the effect of chemical structure and surface properties of synthetic polymers on the coagulation of blood. The ultimate goal of these studies is the development of satisfactory prostheses to replace damaged veins, bypass obstructed arteries of small diameter (less than 6 mm) and for use in aortocoronary surgery. Currently, the surgeon is forced to use autogenous tissue such as the saphenous vein in these situations because of the lack of good synthetic polymer prostheses. Although the results using autogenous saphenous veins are very good, this method has certain disadvantages. Some patients (10 to 25%) do not have satisfactory veins either because of prior removal, disease (varicosities), or because the vein is of inadequate size. Even with patients having satisfactory veins, one has to contend with the problem of limited quantity and a significant increase in operating time. The presently available synthetic polymer prostheses are made from relatively thrombogenic polymers (Teflon and Dacron). These materials show patency rates of less than 50% at diameters smaller than 6 mm. Therefore, the development of a successful, small diameter synthetic polymer prosthesis is of utmost importance to both the patient and the surgeon.

Keywords

Latex Rubber Vascular Prosthesis Natural Artery Elastic Index Autogenous Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Reference

  1. 1.
    D. J. Lyman, L. C. Metcalf, D. Albo, Jr., D. F. Richards, and J. Lamb, Trans. Amer. Soc. Artif. Int. Organs, 20, 474 (1974)Google Scholar
  2. 2.
    E. W. Salzman, Fed. Proc. 30, 1503 (1971)Google Scholar
  3. 3.
    E. Nyilas, Proc. 23rd Ann. Conf. Eng. Med. Biol., 12, 147 (1970)Google Scholar
  4. 4.
    R. C. Dutton, R. E. Baier, R. L. Dedrick, and R. L. Bowman, Trans. Amer. Soc. Artif. Int. Organs, 14, 57 (1968)Google Scholar
  5. 5.
    R. E. Baier and R. C. Dutton, J -Biomed. Mat. Res., 3, 191 (1969)CrossRefGoogle Scholar
  6. 6.
    H. Petscheck, D. Adams, and A. R. Kantrowitz, Trans. Amer. Soc. Artif. Int. Organs, 14, 256 (1968)Google Scholar
  7. 7.
    R. E. Baier, G. I. Loeb, and G. T. Wallace, Fed. Proc., 30, 1523 (1971)Google Scholar
  8. 8.
    A. J. Lande, L. Edwards, J. H. Bloch, R. G. Carlson, V. Subramanian, R. S. Ascheim, S. Scheidt, S. Fillmore, T. Killip, and C. W. Lillehei, Trans. Amer. Soc. Artif. Int. Organs, 16, 352 (1970)Google Scholar
  9. 9.
    D. J. Lyman, K. G. Klein, J. J. Brash, B. K. Fritzinger, J. D. Andrade, and F. S. Bonomo, Thromb. Diath. Haem. Suppl., 42, 109 (1971)Google Scholar
  10. 10.
    D. E. Scarborough, R. G. Mason, F. G. Dalldorf, and K. M. Brink-house, Lab. Invest., 20, 164 (1969)Google Scholar
  11. 11.
    D. J. Lyman, K. G. Klein, J. L. Brash, and B. K. Fritzinger, Thromb. Diathes. Haem., 23, 120 (1970)Google Scholar
  12. 12.
    M. A. Packham, G. Evans, M. F. Glynn, and J. F. Mustard, J. Lab. Clin. Med., 73, 686 (1969)Google Scholar
  13. 13.
    V. L. Gott and A. Furuse, Fed. Proc., 30, 1679 (1971)Google Scholar
  14. 14.
    D. S. P. Jenkins, M. A. Packham, M. A. Gucciore, and J. F. Mustard, J. Lab. Clin. Med., 81, 280 (1973)Google Scholar
  15. 15.
    J. F. Mustard, M. F. Glynn, E. E. Nishizawa, and M. A. Packham, Fed. Proc., 26, 106 (1967)Google Scholar
  16. 16.
    S. W. Kim and D. J. Lyman, App. Polymer Symp., 22, 189 (1973)Google Scholar
  17. 17.
    S. W. Kim, R. G. Lee, C. Adamson, and D. J. Lyman, Preprints Div. of Plastics and Organic Coatings, ACS, 165 36 (1973)Google Scholar
  18. 18.
    M. F. Glynn, M. A. Packham, J. Kirsh, and J. F. Mustard, J. Clin. Invest., 45, 1013 (1966)Google Scholar
  19. 19.
    M. B. Zucker and L. Vroman, Proc. Soc. Biol. Med., 131, 318 (1969)CrossRefGoogle Scholar
  20. 20.
    D. J. Lyman and W. J. Seare, Jr., Ann. Revs. Maters. Sci., 4, 415 (1974)ADSCrossRefGoogle Scholar
  21. 21.
    D. J. Lyman, K. Knutson, B. McNeil, and K. Shibatani, Trans. Amer. Soc. Artif. Int. Organs, 21, 49 (1975)Google Scholar
  22. 22.
    D. J. Lyman, D. Albo, Jr., R. Jackson, and K. Knutson, Trans. Amer. Soc. Artif. Int. Organs, 23, 253 (1977)CrossRefGoogle Scholar
  23. 23.
    D. J. Lyman, F. J. Fazzio, H. Voorhees, G. Robinsons, and D. A.bo, Jr., J. Biomed. Maters. Res., 12, 337 (1978)CrossRefGoogle Scholar
  24. 24.
    D. J. Lyman, C. Kwan-Gett, H. J. Zwart, A. Bland, N. Eastwood, J. Kawai, and W. J. Kolff, Trans. Amer. Soc. Artif. Int. Organs, 17, 456 (1971)Google Scholar
  25. 25.
    D. E. Hokanson and E. E. Strandness, Surg. Gynecol. Obstet., 127 57 (1968)Google Scholar
  26. 26.
    E. R. Gozna, W. F. Mason, A. E. Marble, et al., Can. J. Surg., 15, 176 (1974)Google Scholar
  27. 27.
    W. V. Sharp and W. H. Falor, Am. J. Surg., 105, 802 (1963)CrossRefGoogle Scholar
  28. 28.
    W. V. Sharp, A. F. Finelli, W. H. Falor, and J. W. Ferraro, Circulation, 29 (suppl.) 165 (1964)Google Scholar
  29. 29.
    W. V. Sharp, D. L. Gardner, and G. J. Andresen, Trans. Amer. Soc. Artif. Internal Organs, 11, 336 (1965)CrossRefGoogle Scholar
  30. 30.
    B. Dreyer, T. Akutsu, and W. J. Kolff, J. Appl. Physiol., 15, 18 (1960)Google Scholar
  31. 31.
    V. Marinescu, E. Pausescu, and S. Carnaru, Thorax, 26, 108 (1971)CrossRefGoogle Scholar
  32. 32.
    M. Wagner, G. Reul, J. Teresi, and K. L. Kayser, Am. J. Surg., 3, 838 (1966)CrossRefGoogle Scholar
  33. 33.
    H. D. Berkowitz, L. J. Perloff, and B. Roberts, Surgery, 72, 888 (1972)Google Scholar
  34. 34.
    W. V. Sharp, D. L. Gardner, and G. J. Andresen, Trans. Amer. Soc. Artif. Int. Organs, 12, 179 (1966)Google Scholar
  35. 35.
    W. V. Sharp, D. L. Gardner, G. J. Andresen, and J. Wright, Trans. Amer. Soc. Artif. Int. Organs, 14, 73 (1968)Google Scholar
  36. 36.
    D. J. Lyman and R. H. Knowlton, Manuscript in preparation.Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Donald J. Lyman
    • 1
  • Kenneth B. Seifert
    • 1
  • Helene Knowlton
    • 1
  • Dominic AlboJr.
    • 1
  1. 1.Department of Materials Science and Engineering and Department of SurgeryUniversity of UtahSalt Lake CityUSA

Personalised recommendations