Sialobiology and the Polysialic Acid Glycotope Occurrence, Structure, Function, Synthesis, and Glycopathology

  • Frederic A. TroyII


Polysialic acids (polySia)* are a structurally diverse family of linear carbohydrate chains that consist of N-acetylneuraminic acid (Neu5Ac) or N-glycolylneuraminic acid (Neu5Gc) residues, usually joined internally by α2,8-, α2,9-, or alternating α2,8-/α2,9-ketosidic linkages. 3-Deoxy-D-glycero-D-galacto-2- nonulosonic acid (KDN) is a unique deaminated form of Sia, and polyKDN chains share many properties in common with polySia (Table I). The finding of poly(Neu5Ac), poly(Neu5Gc), poly(Neu5Ac,Neu5Gc), poly(KDN) chains and their partially O-acetylated and O-lactylated forms in salmonid fish egg glycoproteins demonstrates the natural occurrence of multiple forms of these unique sugar chains.


Sialic Acid Neural Cell Adhesion Molecule Polysialic Acid Cortical Vesicle Jelly Coat 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Frederic A. TroyII
    • 1
  1. 1.Department of Biological ChemistryUniversity of California, School of MedicineDavisUSA

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