Depression in Alcoholism

  • Alec Roy
  • Markku Linnoila
Part of the The Depressive Illness Series book series (DISS, volume 4)

Abstract

In recent years a number of studies have reported a high lifetime prevalence of psychiatric disorders among alcoholics (Weissman et al., 1980; Hesselbrock et al., 1985; Schuckit, 1985; Ross et al., 1988; Roy et al., 1991). For example, one or more additional lifetime psychiatric disorders. meeting DSM-III criteria was found among 77% of 321 and 80.2% of 339 alcoholics by Hesselbrock et al. (1985) and Roy et al. (1991), respectively. Both these reports noted that major depression was the most common associated diagnosis among women alcoholics. That referral factors to psychiatric settings play a part in these results was recently demonstrated by Regier et al. (1990). They found that among the 20,291 individuals interviewed in the National Institute of Mental Health (NIMH) Epidemiologic Catchment Area (ECA) Program, 37% of the alcoholics had a comorbid mental disorder. However, 55% of their alcoholics in specialty treatment had a comorbid mental disorder.

Keywords

Depressed Patient Natural Killer Cell Activity Harm Avoidance Epidemiologic Catchment Area Comorbid Mental Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Axelrod J, Reisine D: Stress hormones: Their interaction and regulation. Science 1984; 224: 452–459.PubMedCrossRefGoogle Scholar
  2. Brown S, Schuckit M: Changes in depression among abstinent alcoholics. J Stud Alcohol 1988; 49: 412–417.PubMedGoogle Scholar
  3. Buydens-Branchey L, Branchey M, Noumair D: Age of alcoholism onset, I: Relationship to psychopathology. Arch Gen Psychiatry 1989; 46: 229–230.Google Scholar
  4. Buydens-Branchey L, Branchey M, Noumair D, Lieber C: Age of alcoholism onset, II: Relationship to susceptibility to serotonin precursor availability. Arch Gen Psychiatry 1989; 46: 231–236.PubMedCrossRefGoogle Scholar
  5. Cloninger R: Gene-environment interaction in the familial relationship of alcoholism, depression and antisocial personality. Chap. 23. In: Edwards G, Littleton J (Eds.) Pharmacological Treatments for Alcoholism. London: Croom Helm, 1984, 417–444.Google Scholar
  6. Cloninger R: Neurogenetic adaptive mechanisms in alcoholism. Science 1987; 236: 410–416.PubMedCrossRefGoogle Scholar
  7. Cloninger R, Reich T, Wetzel R: Alcoholism and affective disorders: Familial associations and genetic models. Chap. 6. In: Goodwin and Erickson (Eds.) Alcoholism and Affective Disorders. Clinical, Genetic and Biochemical Studies. New York: Spectrum Publications, 1979, 57–86.Google Scholar
  8. Cook B, Winokur G, Garvey M, Beach V: Depression and previous alcoholism in the elderly. Br J Psychiatry 1991; 158: 72–75.PubMedCrossRefGoogle Scholar
  9. Davis K, Davis B, Mohs R, et al: CSF corticotropin releasing factor in neuropsychiatric diseases. In: New Research Abstracts, 137th Annual Meeting of the American Psychiatric Association. Washington, DC: APA, 1984.Google Scholar
  10. Fowler R, Liskow B, Tanna V: Alcoholism, depression, and life events. J Affective Disord 1980; 2: 127–135.CrossRefGoogle Scholar
  11. Gold P, Loriaux L, Roy A, et al: Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing’s disease. Pathophysiologic and diagnostic implications. N Engl J Med 1986; 314: 1330–1335.Google Scholar
  12. Golding J, Burnam A, Wells K: Alcohol use and depressive symptoms among Mexican Americans and non-Hispanic whites. Alcohol Alcohol 1990; 25: 421–432.PubMedGoogle Scholar
  13. Hasin D, Endicott J, Keller M: RDC alcoholism in patients with major affective syndromes. Am J Psychiatry 1989; 146: 318–323.PubMedGoogle Scholar
  14. Hesselbrock M, Meyer R, Keener J: Psychopathology in hospitalized alcoholics. Arch Gen Psychiatry 1985; 42: 1050–1055.PubMedCrossRefGoogle Scholar
  15. Hirschfeld R, Klerman G, Clayton P, Keller M, McDonald-Scott P, Larkin B: Assessing personality: Effects of the depressive state on trait measurement. Am J Psychiatry 1983; 140: 695–699.PubMedGoogle Scholar
  16. Hirschfeld R, Kosier T, Keller M, Lavori P, Endicott J: The influence of alcoholism on the course of depression. J Affective Disord 1989; 16: 151–158.CrossRefGoogle Scholar
  17. Irwin M, Caldwell C, Smith T, Brown S, Schuckit M, Gillin C: Major depressive disorder, alcoholism, and reduced natural killer cell cytotoxicity. Arch Gen Psychiatry 1990; 47: 713–719.PubMedCrossRefGoogle Scholar
  18. Irwin M, Risch C, Brown S, Howard T, Smith T, Knapp S, Schuckit M: Urinary free cortisol excretion in depressed alcoholic patients. Biol Psychiatry 1988; 24: 713–716.PubMedCrossRefGoogle Scholar
  19. Kling M, Roy A, Doran A, Calabrese J, Rubinow D, Whitfield H, May C, Post R, Chrousos G, Gold P: Cerebrospinal fluid immunoreactive CRH and ACTH secretion in Cushing’s disease and major depression: Potential clinical implications. J Clin Endocrinol Metab 1990; 72: 260–271.CrossRefGoogle Scholar
  20. Limson R, Goldman D, Roy A, Lamparski D, Ravitz R, Adinoff B, Linnoila M: Personality and CSF monoamine metabolites in alcoholics and controls. Arch Gen Psychiatry 1991; 48: 437–441.PubMedCrossRefGoogle Scholar
  21. Loosen P, Prange A: Serum thyrotropin response to thyrotropin-releasing hor-mone in psychiatric patients: A review. Am J Psychiatry 139: 405–416.Google Scholar
  22. Loosen PT: Thyroid function in depression and alcoholism. Endocrinol Metab Clin North Am 1988; 17: 55–82.PubMedGoogle Scholar
  23. Loosen PT, Dew B, Prange A: Long-term predictors of outcome in abstinent alcoholic men. Am J Psychiatry 1990; 147: 1662–1666.PubMedGoogle Scholar
  24. Loosen PT, Marciniak R, Thadami K: TRH induced TSH response in healthy volunteers: Relationship to psychiatric history. Am J Psychiatry 1987; 144: 455–459.PubMedGoogle Scholar
  25. Loosen PT, Prange AJ Jr, Wilson IC: TRH (protirelin) in depressed alcoholic men: behavioral changes and endocrine responses. Arch Gen Psychiatry 1979; 36: 540–547.PubMedCrossRefGoogle Scholar
  26. Loosen PT, Wilson IC, Dew BW, et al: Thyrotropin-releasing hormone (TRH) in abstinent alcoholic men. Am J Psychiatry 1983; 140: 1145–1149.PubMedGoogle Scholar
  27. Meltzer H, Lowy M: The serotonin hypothesis of depression. Chap 52. In: Meltzer H (Ed.) Psychopharmacology: The Third Generation of Progress, New York: Raven Press, 1987, 513–526.Google Scholar
  28. Merikangas K, Leckman J, Prusoff B, Pauls D, Weissman M: Familial transmis- sion of depression and alcoholism. Arch Gen Psychiatry 1985; 42: 367–372.PubMedCrossRefGoogle Scholar
  29. Merikangas K, Gelernter C: Comorbidity for alcoholism and depression. In: Wesner R, Winokur G, (Eds.) Psychiatric Clinics of North America, Philadelphia: W.B. Saunders, 613–632.Google Scholar
  30. Murray H, Gurling H: Do personality and psychiatric disorders predispose to alcoholism? Chap. 24. In: Edwards G, Littleton J (Eds) Pharmacological Treatments for Alcoholism London: Croom Helm, 1984, 445–462.Google Scholar
  31. Nemeroff C, Bissette G, Aril H, Fink M: Neuropeptide concentrations in the cerebrospinal fluid of depressed patients treated with electroconvulsive ther-apy. Corticotropin releasing factor, B endorphin and somatostatin. Br J Psychiatry 1991; 158: 59–63.PubMedCrossRefGoogle Scholar
  32. O’Hanlon M, Barry S, Clare A, Dinan T: Serum thyrotropin responses to thyrotropin-releasing hormone in alcohol-dependent patients with and without depression. J Affective Disord 1991; 21: 109–115.CrossRefGoogle Scholar
  33. Petty F, Kramer G, Dunnam D: Plasma GABA and Alcoholism. Annual Meeting of Society for Biological Psychiatry, New Orleans, 1991. Abstract 99.Google Scholar
  34. Regier D, Farmer M, Rae D, Locke B, Keith S, Judd L, Goodwin F: Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. J Am Med Assoc 1990; 264: 2511–2518.CrossRefGoogle Scholar
  35. Roy A: Personality variables in depressed patients and normal controls. Neuropsychobiology 1990; 23: 119–123.PubMedCrossRefGoogle Scholar
  36. Roy A, DeJong J, Adinoff B, Barbaccia M, Costa E, Guidotti A, Linnoila M: CSF diazepam-binding inhibitor in alcoholics and normal controls. Psychiatry Res 1990; 31: 261–266.PubMedCrossRefGoogle Scholar
  37. Roy A, DeJong J, Gold P, Rubinow D, Adinoff B, Ravitz B, Waxman R, Linnoila M: CSF somatostatin, CRH, and ACTH in alcoholics and controls. Acta Psychiatr Scand 1990; 82: 44–48.PubMedCrossRefGoogle Scholar
  38. Roy A, DeJong J, Ferraro T, Adinoff B, Ravitz B, Linnoila M: GABA in alcoholics and controls. Am J Psychiatry 1990; 147: 1294–1296.PubMedGoogle Scholar
  39. Roy A, Linnoila M: Alcoholism and suicide. Suicide Life Threat Behav 1986; 16: 244–273.PubMedGoogle Scholar
  40. Roy A, Pickar D: TRH-induced prolactin release in unipolar depressed patients and controls. J Psychiatr Res 1988b; 22: 221–225.PubMedCrossRefGoogle Scholar
  41. Roy A, Karoum F, Linnoila M, Pickar D: Thyrotropin releasing hormone test in unipolar depressed patients and controls: relationship to clinical and biological variables. Acta Psychiatr Scand 1988a; 77: 151–159.PubMedCrossRefGoogle Scholar
  42. Roy A, Pickar D, Linnoila M, Doran A, Ninan P, Paul S: Cerebrospinal fluid monoamines and monoamine metabolites in melancholia. Psychiatry Res 1985; 15: 281–292.PubMedCrossRefGoogle Scholar
  43. Roy A, Pickar D, Paul S: Biologic tests for depression. Psychosomatics 1984; 25: 443–451.PubMedCrossRefGoogle Scholar
  44. Roy A, Pickar D, Paul S, Doran A, Gold P: Cerebrospinal fluid corticotropin releasing factor in depressed patients and normal controls. Am J Psychiatry 1987; 144: 641–645.PubMedGoogle Scholar
  45. Roy A, Pickar D, DeJong J, Karoum F, Linnoila M: Norepinephrine and its metabolites in CSF, plasma, and urine: relationship to hypothalamic-pituitaryadrenal axis function in depression. Arch Gen Psychiatry 1988; 45: 849–857.PubMedCrossRefGoogle Scholar
  46. Roy A, DeJong J, Lamparski D, Adinoff B, George T, Moore V, Garnett D, Kerich M, Linnoila M: Mental disorders among alcoholics. Relationship to age of onset and cerebrospinal fluid neuropeptides. Arch Gen Psychiatry 1991; 48: 423–427.PubMedCrossRefGoogle Scholar
  47. Roy A, DeJong J, Lamparski D, George T, Linnoila M: Depression among alco-holics. Relationships to clinical and cerebrospinal fluid variables. Arch Gen Psychiatry 1991; 48: 428–432.PubMedCrossRefGoogle Scholar
  48. Rudorfer M, Risby E, Osman O, Gold P, Potter W: Hypothalamic-pituitaryadrenal axis and monoamine transmitter activity in depression: a pilot study of central and peripheral effects of electroconvulsive therapy. Biol Psychiatry 1991; 29: 253–264.PubMedCrossRefGoogle Scholar
  49. Schuckit, M: The clinical implications of primary diagnostic groups among alcoholics. Arch Gen Psychiatry 1985; 42: 1043–1049.PubMedCrossRefGoogle Scholar
  50. Schuckit M: Genetic and clinical implications of alcoholism and affective disorders. Am J Psychiatry 1986; 143: 140–147.PubMedGoogle Scholar
  51. Stein M, Miller A, Trestman R: Depression, the immune system, and health and illness. Arch Gen Psychiatry 1991; 48: 171–177.PubMedCrossRefGoogle Scholar
  52. Vrasti R, Enasescu N, Poelinca C, Apostol V: Interpersonal dependency, self-esteem and depression in primary alcoholism. Acta Psychiatr Scand 1988; 78: 448–450.PubMedCrossRefGoogle Scholar
  53. Willenbring M, Anton F, Spring W, Shafer R, Dorus W: Thyrotropin and prolactin response to thyrotropin-releasing hormone in depressed and non-depressed alcoholic men. Biol Psychiatry 1990; 27: 31–38.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Alec Roy
    • 1
  • Markku Linnoila
    • 2
  1. 1.Veterans Administration HospitalBrooklynUSA
  2. 2.National Institute on Alcohol Abuse and AlcoholismBethesdaUSA

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