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Biology of Bipolar Disorder

  • Chapter
Book cover Biology of Depressive Disorders

Part of the book series: The Depressive Illness Series ((DISS,volume 4))

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Abstract

This chapter will discuss biological studies of bipolar disorder from two points of view. The first is that of direct or indirect studies of brain function, generally cross-sectional, in patients with bipolar disorder. This is not intended to be an exhaustive review, but will focus on recent evidence distinguishing the phases of bipolar disorder, or differentiating patients with bipolar disorder from unipolar depressed and healthy subjects. Results will be discussed in larger contexts of physiology, models, and treatment.

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References

  • Afione S, Duvilanski B, Seilicovich A, Lasaga M, Diaz MDC, Debeljuk L: Effects of serotonin on the hypothalamic-pituitary GABAergic system. Brain Res Bull 1990; 25: 245–259.

    PubMed  CAS  Google Scholar 

  • Ambelas, A; Life events and mania: A special relationship? Br J Psychiatry 1987; 150: 235–240.

    PubMed  CAS  Google Scholar 

  • Angst, J: Switch from depression to mania—A record study over decades between 1920 and 1982. Psychopathology 1985; 18: 140–154.

    PubMed  CAS  Google Scholar 

  • Ansseau M, von Frenckell R, Cerfontain JL, Papart P, Franck G, Timsit-Berthier

    Google Scholar 

  • M, Geenen V, Legros J-J: Neuroendocrine evaluation of catecholaminergic neurotransmission in mania. Psychiatry Res 1987; 22: 193–206.

    Google Scholar 

  • Artigas F, Sarias MJ, Martinez E, Gelpi E, Alvarez E, Udina C: Increased plasma free serotonin but unchanged platelet serotonin in bipolar patients treated with lithium. Psychopharmacology 1989; 99: 328–332.

    PubMed  CAS  Google Scholar 

  • Aston-Jones G, Akaoka H, Charlety P, Chouvet G: Serotonin selectively attenuates glutamate-evoked activation of noradrenergic locus coeruleus neurons. J Neurosci 1991; 99: 760–769.

    Google Scholar 

  • Avissar S, Schreiber G: Muscarinic receptor subclassification and G-proteins: Significance for lithium action in affective disorders and for the treatment of the extrapyramidal side effects of neuroleptics. Biol Psychiatry 1989; 26: 113–130.

    PubMed  CAS  Google Scholar 

  • Azorin JM, Pupeschi G, Valli M, Joanny P, Raucoules D, Lancon C, Tissot R: Plasma 3-methoxy-4-hydroxyphenylglycol in manic patients: Relationships with clinical variables. Acta Psychiat Scand 1990; 81: 14–18.

    PubMed  CAS  Google Scholar 

  • Azorin J-M, Tramoni V: Kindling models and antikindling effects of mood normalizers. Pharmacopsychiatry 1987; 20: 189–191.

    PubMed  CAS  Google Scholar 

  • Berrettini WH, Nurnberger Jr JI, Hare T, Gershon ES, Post RM: Plasma and CSF GABA in affective illness. Br J Psychiatry 1982; 141: 483–487.

    PubMed  CAS  Google Scholar 

  • Berrettini WH, Nurnberger Jr JI, Hare TA, Simmons-Alling S, Gershon ES: CSF GABA in euthymic manic-depressive patients and controls. Biol Psychiatry 1986; 21: 842–844.

    Google Scholar 

  • Berrettini WH, Nurnberger Jr JI, Zerbe RL, Gold PW, Chrousos GP, Tomai T: CSF neuropeptides in euthymic bipolar patients and controls. Br J Psychiatry 1987; 150: 208–212.

    PubMed  CAS  Google Scholar 

  • Berrettini WH, Bardakjian J, Cappellari CB, Barnett Jr AL, Albright A, Nurnberger Jr JI, Gershon ES: Skin fibroblast (3-adrenergic receptor function in manic—depressive illness. Biol Psychiatry 1987; 22: 1439–1443.

    PubMed  CAS  Google Scholar 

  • Biegon A, Essar N, Israeli M, Elizur A, Bruch S, Bar-Nathan AA: Serotonin 5-HT2 receptor binding on blood platelets as a state dependent marker in major affective disorder. Psychopharmacology 1990; 102: 73–75.

    PubMed  CAS  Google Scholar 

  • Borsook D, Richardson GS, Moore-Ede MC, Brennan MJW: GABA and circadian timekeeping: Implications for manic-depression and sleep disorders. Med Hypotheses 1986; 19: 185–198.

    PubMed  CAS  Google Scholar 

  • Bowden CL, Huang LG, Javors MA, Johnson JM, Seleshi E, McIntyre K, Contreras S, Maas JW: Calcium function in affective disorders and healthy controls. Biol Psychiatry 1988; 23: 367–376.

    PubMed  CAS  Google Scholar 

  • Breier A, Albus M, Pickar D, Zahn TP, Wolkowitz OM, Paul SM: Controllable and uncontrollable stress in humans: Alterations in mood and neuroendocrine and psychophysiological function. Am J Psychiatry 1987; 144: 1419–1425.

    PubMed  CAS  Google Scholar 

  • Bryan Jr RM: Cerebral blood flow and energy metabolism during stress. Am J Physiology 1990; H269 — H280.

    Google Scholar 

  • Buchsbaum MS, Post RM, Bunney Jr WE: Average evoked responses in a rapidly cycling manic—depressive patient. Biol Psychiatry 1977; 12: 83–99.

    PubMed  CAS  Google Scholar 

  • Buckholtz NS, Davies AO, Rudorfer MV, Golden RN, Potter WZ: Lymphocyte ß adrenergic receptor function versus catecholamines in depression. Biol Psychiatry 1988; 24: 451–457.

    PubMed  CAS  Google Scholar 

  • Bunney Jr WE, Hartmann EL, Mason JW: Study of a patient with 48-hour manic-depressive cycles: Part II. Strong positive correlation between endocrine factors and manic defense patterns. Arch Gen Psychiatry 1965; 12: 619–625.

    PubMed  Google Scholar 

  • Bunney Jr WE, Murphy DL, Goodwin FK, Borge GF: The “switch process” in manic—depressive illness: I. A systematic study of sequential behavioral changes. Arch Gen Psychiatry 1972; 27: 295–302.

    PubMed  Google Scholar 

  • Bunney Jr WE, Goodwin FK, Murphy DL, House KM, Gordon EK: The “switch process” in manic—depressive illness: II. Relationship to catecholamines, REM sleep, and drugs. Arch Gen Psychiatry 1972b; 27: 304–309.

    PubMed  Google Scholar 

  • Bunney WE, Goodwin FK, Murphy DL: The “switch process” in manic—depressive illnesses: III. Theoretical implications. Arch Gen Psychiatry 1972c; 27: 312–317.

    PubMed  CAS  Google Scholar 

  • Carney MWP, Chary TKN, Bottiglieri T, Reynolds EH: The switch mechanism and the bipolar/unipolar dichotomy. Br J Psychiatry 1989; 154: 48–51.

    PubMed  CAS  Google Scholar 

  • Christie JE, Whalley LJ, Dick H, Blackwood DHR, Blackburn IM, Fink G: Raised plasma cortisol concentrations a feature of drug-free psychotics and not specific for depression. Br J Psychiatry 1986; 148: 58–65.

    PubMed  CAS  Google Scholar 

  • Coccaro EF, Siever LJ, Klar HM, Maurer G, Cochrane K, Cooper TB, Mohs RC, Davis KL: Serotonergic studies in patients with affective and personality disorders. Arch Gen Psychiatry 1989; 46: 587–599.

    PubMed  CAS  Google Scholar 

  • Cohen BM, Lipinsky JF, Altesmar RF: Lecithin in the treatment of mania. Am J Psychiatry 1982; 139: 1162–1164.

    PubMed  CAS  Google Scholar 

  • Cohen RM, Semple WE, Gross M, Nordahl TE, King AC, Pickar D, Post RM: Evidence for common alterations in cerebral glucose metabolism in major affective disorders and schizophrenia. Neuropsychopharmacology 1989; 2: 241–254.

    PubMed  CAS  Google Scholar 

  • Cole AJ, Saffen DW, Baraban JM, Worley PF: Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation. Nature 1989; 340: 474–476.

    PubMed  CAS  Google Scholar 

  • Cole BJ, Cador M, Stinus L, Rivier J, Vale W, Koob GF, le Moal M: Central administration of a CRF antagonist blocks the development of stress-induced behavioral sensitization. Brain Res 1990; 512: 343–346.

    PubMed  CAS  Google Scholar 

  • Colley PA, Sheu F-S, Routtenberg A: Dose-dependent facilitation or blockade of hippocampal long-term potentiation: Relation to membrane/cytosol distribution of protein kinase-C activity. Brain res 1989; 495: 205–216.

    PubMed  CAS  Google Scholar 

  • Cowdry RW, Wehr TA, Zis AP, Goodwin FK: Thyroid abnormalities associated with rapid-cycling bipolar illness. Arch Gen Psychiatry 1983; 40: 414–420.

    PubMed  CAS  Google Scholar 

  • Cutler NR, Post RM: Life course of illness in untreated manic—depressive patients. Comprehensive Psychiatry 1982; 23: 101–115.

    PubMed  CAS  Google Scholar 

  • Dagher G, Gay C, Brossard M, Feray JC, Olie JP, Garay RP, Loo H, Meyer P: Lithium, sodium, and potassium transport in erythrocytes of manic-depressive patients. Acta Psychiat Scand 1984; 69: 24–36.

    PubMed  CAS  Google Scholar 

  • Dahl D, Sarvey JM: Norepinephrine induces pathway-specific long-lasting potentiation and depression in the hippocampal dentate gyrus. Proc Nat Acad Sci USA 1989; 86: 4776–4780.

    CAS  Google Scholar 

  • De Paermentier F, Cheetham SC, Crompton MR, Katona CLA, Horton RW: Brain f3-adrenoceptor binding sites in antidepressant-free depressed suicide victims. Brain Res 1990; 525: 71–77.

    PubMed  Google Scholar 

  • Delgado PL, Charney DS, Price LH, et al.: Serotonin function and the mechanism of antidepressant action—Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry 1990; 47: 411–418.

    PubMed  CAS  Google Scholar 

  • DeMontigny C, Courmoyer G, Morisette B, Langlois R, Caille G: Lithium carbonate addition in tricyclic antidepressant-resistant depression: Correlations with the neurobiologic actions of tricyclic antidepressant drugs and lithium ion on the serotonin system, Arch Gen Psychiatry 1983; 40: 1327–1434.

    CAS  Google Scholar 

  • Depue RA, Kleiman RM, Davis P, Hutchinson M, Krauss SP: The behavioral high-risk paradigm and bipolar affective disorder: VIII. Serum free cortisol in nonpatient cyclothymic subjects selected by the General Behavior Inventory. Am J Psychiatry 1985; 142: 175–181.

    PubMed  CAS  Google Scholar 

  • Di Simoni MG, Dal Toso G, Fodritto F, Sokola A, Algeri S: Modulation of striatal dopamine metabolism by the activity of dorsal raphe serotonergic afferents. Brain Res 1987; 411: 81–88.

    PubMed  Google Scholar 

  • Dragunow M, Robertson HA: Kindling stimulation induces c-fos proteins in granule cells of rat dentate gyrus. Nature 1987; 329: 441–442.

    PubMed  CAS  Google Scholar 

  • Drummand AH, Maclntyre DE: Protein kinase C as a bidirectional regulator of cell function. Trends Pharmacol Sci 1985; 8: 233–234.

    Google Scholar 

  • Dubovsky SL, Christiona J, Daniell LC, Franks RD, Murphy J, Adler L, Baker N, Harris RA: Increased platelet intracellular calcium concentration in patients with bipolar affective disorders. Arch Gen Psychiatry 1989; 46: 632–638.

    PubMed  CAS  Google Scholar 

  • Dunlap K, Holz GC, Rane SG: G proteins as regulators of ion channels. Trends Neurosci 1987; 10: 241–244.

    PubMed  CAS  Google Scholar 

  • Dupont RM, Jernigan TL, Butters N, Delis D, Hesselink JR, Heindel W, Gillin JC: Subcortical abnormalities detected in bipolar affective disorder using magnetic resonance imaging. Arch Gen Psychiatry 1990; 47: 55–59.

    PubMed  CAS  Google Scholar 

  • Ebstein RP, Lerer B, Bennett ER, Shapira B, Kindler S, Shemesh Z, Gerstenhaber N: Lithium modulation of second messenger signal amplification in man: Inhibition of phosphatidylinostiol-specific phospholipase C and adenylate cyclase activity. Psychiat Res 1988; 24: 45–52.

    CAS  Google Scholar 

  • El-Mallakh, RS: The Na,K-ATPase hypothesis for manic-depression. I. General considerations. Med Hypotheses 1983; 12: 253–268.

    PubMed  CAS  Google Scholar 

  • El-Mallakh RS, Jaziri WA: Calcium channel blockers in affective illness: Role of sodium-calcium exchange. J Clin Psychopharmacol 1990; 10: 203–206.

    PubMed  CAS  Google Scholar 

  • Ellicott A, Hammen C, Gitlin M, Brown G, Jamison K: Life events and the course of bipolar disorder. Am J Psychiatry 1990; 147: 1194–1198.

    PubMed  CAS  Google Scholar 

  • Ellis J, Lenox, RH: Chronic lithium treatment prevents atropine-induced supersensitivity of the muscarinic phosphoinositide response in rat hippocampus. Biol Psychiatry 1990; 28: 609–619.

    PubMed  Google Scholar 

  • Evans DA, Nemeroff CB: The dexamethasone suppression test in mixed bipolar disorder. Am J Psychiatry 1982; 140: 615–617.

    Google Scholar 

  • Freed WJ, Cannon-Spoor HE: A possible role of AA2 excitatory amino acid receptors in the expression of stimulant drug effects. Psychopharmacology 1990; 101: 456–464.

    PubMed  CAS  Google Scholar 

  • Gellman RL, Kallianos JA, McNamara JO: A-2 receptors mediate an endogenous noradrenergic suppression of kindling development. J Pharmacol Exp Therapeut 1987; 241: 891–898.

    CAS  Google Scholar 

  • Gerner RA, Post RM, Bunney Jr WE: A dopaminergic mechanism in mania. Am J Psychiatry 1986; 133: 1177–1180.

    Google Scholar 

  • Gilbert ME, Mack CM: The NMDA antagonist, MK-801, suppresses long-term potentiation, kindling, and kindling-induced potentiation in the perforans path of the unanesthetized rat. Brain Res 1990; 519: 89–96.

    PubMed  CAS  Google Scholar 

  • Gillin JC, Borbely AA: Sleep: A neurobiological window on affective disorders. Trends Neurol Sci 1985; 10: 537–542.

    Google Scholar 

  • Glue PW, Cowen PJ, Nutt DJ, Kolakowska T, Grahame-Smith DG: The effect of lithium on 5-HT-mediated neuroendocrine responses and platelet 5-HT receptors. Psychopharmacology 1986; 90: 398–402.

    PubMed  CAS  Google Scholar 

  • Godwin CD, Greenberg LB, Shukla S: Predictive value of the dexamethasone suppression test in mania. Am J Psychiatry 1984; 141: 1610–1612.

    PubMed  CAS  Google Scholar 

  • Goh JW, Pennefather PS: Pertussis toxin prevents induction of hippocampal long-term potentiation in the striatum radiatum and stratum oriens to CA1 neurons. Brain Res 1990; 511: 345–348.

    PubMed  CAS  Google Scholar 

  • Goodwin FK, Post RM: 5-hydroxytryptamine and depression: A model for the interaction of normal variance with pathology. Br J Clin Pharmacol 1983; 15: 393S - 405S.

    PubMed  Google Scholar 

  • Goplerud E, Depue RA: Behavioral response to naturally occurring stress in cyclothymia and dysthymia. J Abnormal Psychol 1985; 94: 128–139.

    CAS  Google Scholar 

  • Grahnstedt S, Ellertsen B: Brain state and kindled seizures. Exp Neurol 1984; 84: 596–605.

    PubMed  CAS  Google Scholar 

  • Greenspan K, Schildkraut JJ, Gordon EK, Baer L, Aronoff MS, Durell J: Catecholamine metabolism in affective disorders: III. MHPG and other catecholamine metabolites inpatients treated with lithium carbonate. J Psychiat Res 1970; 7: 171–183.

    PubMed  CAS  Google Scholar 

  • Greil W, Eisenreid F, Becker BF, Duhm J: Interindividual differences in the Na+-dependent Li+ counter transport system and in the Li+ distribution ratio across the red cell membrane among lithium-treated patients. Psycho-pharmacology 1977; 53: 19–26.

    CAS  Google Scholar 

  • Grunhaus L, Tiongco D, Zelnik T, Flegel P, Hollingsworth PI, Smith CB: Intravenous yohimbine: Selective enhancer of norepinephrine and cortisol secretion and systolic blood pressure in humans. Clin Neuropharmacol 1989; 12: 106–114.

    PubMed  CAS  Google Scholar 

  • Haggerty JJ, Sinmon JS, Evans DL, Nemeroff CB: Relationship of serum TSH concentration and antithyroid antibodies to diagnosis and DST response in psychiatric inpatients. Am J Psychiatry 1987; 144; 1491–1493.

    PubMed  Google Scholar 

  • Harvey BH, Carstens ME, Taljaard JJ: A novel hypothesis for the psycho-modulating effects of lithium: The role of essential fatty acids, eicosanoids, and sub-cellular second messengers. Med Hypotheses 1990; 32: 51–58.

    PubMed  CAS  Google Scholar 

  • Hayward MD, Duman RS, Nestler EJ: Induction of the c-fos protooncogene during opiate withdrawal in the locus coeruleus and other regions of rat brain. Brain Res 1990; 525: 256–266.

    PubMed  CAS  Google Scholar 

  • Hensler JG, Ordway GA, Gambarana C, Areso P, Frazer A: Serotonergic neurons do not influence the regulation of beta adrenoceptors by either desipramine or isoproterenol. J Pharmacol Exp Therapeutics 1991; 256: 656–664.

    CAS  Google Scholar 

  • Hernandez TD, Rosen JB, Gallager DW: Long-term changes in sensitivity to GABA in dorsal raphe neurons following amygdala kindling. Brain Res 1990; 517: 294–300.

    PubMed  CAS  Google Scholar 

  • Hilakivi LA, Hilakivi I: Increased adult behavioral “despair” in rats neonatally exposed to desipramine or zimelidine: An animal model of depression? Pharmacol Biochem Behav 1987; 28: 367–369.

    PubMed  CAS  Google Scholar 

  • Hitzemann R, Mark C, Hirshowitz J, Garver D: RBC lithium transport in the psychoses. Biol Psychiatry 1989; 25: 296–304.

    PubMed  CAS  Google Scholar 

  • Hughes CW, Kent TA, Campbell J, Oke A, Croskell H, Preskorn S: Cerebral blood flow and cerebrovascular permeability in an inescapable shock (learned helplessness) animal model of depression. Pharmacol Biochem Behav 1984; 21: 891–894.

    PubMed  CAS  Google Scholar 

  • Iandorola MJ, Nicoletti F, Naranjo JR, Putnam F, Costa E: Kindling enhances the stimulation of inositol phospholipid hydrolysis elicited by ibotenic acid in rat hippocampal slices. Brain Res 1986; 374: 174–178.

    Google Scholar 

  • Janowsky DS, El-Yousef M-K, Davis JM, Sekerke HJ: A cholinergic—adrenergic hypothesis for mania and depression. Lancet 1972; 2: 632–635.

    PubMed  CAS  Google Scholar 

  • Janowsky DS, Davis JM, El-Yousef M-K, et al.: Acetylcholine and depression. Psychosom Med 1974; 36: 248–257.

    PubMed  CAS  Google Scholar 

  • Jarvie PA, Logan TC, Geula C, Slevin JT: Entorhinal kindling permanently enhances Ca2+-dependent L-glutamate release in region inferior of rat hippo-campus. Brain Res 1990; 508: 188–193.

    PubMed  CAS  Google Scholar 

  • Jerushalmy Z, Modai I, Chachkes O, Mark M, Valewski A, Chachkes M, Tyano S: Kinetic values of active serotonin transport by platelets of bipolar, unipolar and schizophrenic patients at 2 and 8 a.m. Neuropsychobiology 1988; 20: 57–61.

    PubMed  CAS  Google Scholar 

  • Jesberger JA, Richardson JS: Animal models of depression: Parallels and corre-

    Google Scholar 

  • lates to severe depression in humans. Biol Psychiatry 1985; 20: 764–784.

    Google Scholar 

  • Joffe RT, Kutcher S, MacDonald C: Thyroid function and bipolar affective disorder. Psychiat Res 1988; 25: 117–121.

    CAS  Google Scholar 

  • Jope RS: Effect of lithium treatment in vitro and in vivo on acetylcholine metabolism in rat brain. J Neurochem 1979; 33: 487–495.

    PubMed  CAS  Google Scholar 

  • Josephson AM, MacKenzie TB: Thyroxine-induced mania in hypothyroid patients. Br J Psychiatry 1980; 137: 222–228.

    PubMed  CAS  Google Scholar 

  • Joyce PR, Donald RA, Livesay JH, Abbott RM: The prolactin response to metaclopramide is increased in depression and in euthymic rapid cycling bipolar patients. Biol Psychiatry 1987; 22: 508–512.

    PubMed  CAS  Google Scholar 

  • Kaczmarek LK: The role of protein kinase C in the regulation of ion channels and neurotransmitter release. Trends Neurol Sci 1987; 10: 30–34.

    CAS  Google Scholar 

  • Kalasapudi VD, Sheftel G, Divish MM, Papolos DF, Lachman HM: Lithium augments fos protooncogene expression in PC12 pheochromocytoma cells: Implications for therapeutic action of lithium. Brain Res 1990; 521: 47–54.

    PubMed  CAS  Google Scholar 

  • Karege F, Bovier P, Gaillard J-M, Tissot R: The 3 heterogeneity of 3-methoxy-4hydroxy-pheylglycol levels among depressed patients. Acta Psychiat Scand 1989; 80: 499–504.

    PubMed  CAS  Google Scholar 

  • Karler R, Calder LD, Chaudhry IA, Turkanis SA: Blockade of “reverse tolerance” to cocaine and amphetamine by MK-801. Life Sci 1989; 45: 599–606. Kashibara K, Hamamura T, Okumura K, Otsuki S: Effect of MK-801 on endogenous dopamine release in vivo. Brain Res 1990; 528: 80–82.

    Google Scholar 

  • Kennedy ED, Challiss RA, Nahorski SR: Lithium reduces the accumulation of inositol polyphosphate second messengers following cholinergic stimulation of cerebral cortex slices. J Neurochem 1989; 53: 1652–1655.

    PubMed  CAS  Google Scholar 

  • Kennedy SH, Tighe S, McVey G, Brown GM: Melatonin and cortisol “switches” during mania, depression, and euthymia in a drug-free bipolar patient. J Nery Ment Dis 1989; 177: 300–303.

    CAS  Google Scholar 

  • Kiriike N, Izumiya Y, Nishiwaki S, Maeda Y, Nagata T, Kawakita Y: TRH test and DST in schizoaffective mania, mania, and schizophrenia. Biol Psychiatry 1988; 24: 415–422.

    PubMed  CAS  Google Scholar 

  • Kishimoto H, Takazu O, Ohno S, Yamaguchi T, Fujita H, Kuwahara H, Ishii T, Matsushita M, Yokoi S, Iio M: 11C-glucose metabolism in mania and depressed patients. Psychiatry Res 1987; 22: 81–88.

    PubMed  CAS  Google Scholar 

  • Kling MA, Kellner CH, Post RM, Cowdry RW, Gardner DL, Coppola R, Putnam FW, Gold PW: Neuroendocrine effects of limbic activation by electrical, spontaneous and pharmacologic modes: Relevance to the pathophysiology of affective dysregulation in psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry 1987; 11: 459–481.

    PubMed  CAS  Google Scholar 

  • Koslow SH, Maas J, Bowden C, Davis J, Hanin I, Javaid J: Cerebrospinal fluid and urinary biogenic amines and metabolites in depression, mania, and healthy controls. A univariate analysis. Arch Gen Psychiatry 1983; 40: 999–1010.

    PubMed  CAS  Google Scholar 

  • Kukopoulos A, Caliari B, Tundo A, Minnai G, Floris G, Reginaldi D, Tondo L: Rapid cyclers, temperament, and antidepressants. Comp Psychiatry 1983; 24: 249–258.

    Google Scholar 

  • Kupfer DJ, Carpenter LL, Frank E: Possible role of antidepressants in precipitating mania and hypomania in recurrent depression. Am J Psychiatry 1988; 145: 804–808.

    PubMed  CAS  Google Scholar 

  • Lachman HM, Papolos DF: Abnormal signal transduction: A hypothetical model for bipolar affective disorder. Life Sci 1989; 45: 1413–1426.

    PubMed  CAS  Google Scholar 

  • Lam RW, Berkowitz AL, Berga SL, Clark CM, Kripke DF, Gillin JC: Melatonin suppression in bipolar and unipolar mood disorders. Psychiatry Res 1990; 33: 129–134.

    PubMed  CAS  Google Scholar 

  • Leiva DB: The neurochemistry of mania: A hypothesis of etiology and a rationale for treatment. Prog Neuropsychopharmacol Biol Psychiatry 1990; 14: 423–429.

    PubMed  CAS  Google Scholar 

  • Lewis JL, Winokur G: The induction of mania: A natural history study with controls. Arch Gen Psychiatry 1982; 39: 303–306.

    PubMed  CAS  Google Scholar 

  • Linnoila M, MacDonald E, Reinila M, Leroy A, Rubinow DR, Goodwin FK: RBC membrane adenosine triphosphatase activity in patients with major affective disorders. Arch Gen Psychiatry 1983; 40: 1021–1026.

    PubMed  CAS  Google Scholar 

  • Lista AL: Differential rates of urinary noradrenaline excretion in affective disorders: Utility of a short time sampling procedure. Psychiatry Res 1989; 30: 253–258.

    PubMed  CAS  Google Scholar 

  • Lloyd KG, Zivkovic B, Scatton B, Morselli PL, Bartholini G: The GABAergic hypothesis of depression. Prog Neuropsychopharmacol Biol Psychiatry 1989; 13: 341–351.

    PubMed  CAS  Google Scholar 

  • Lonati-Gallatini M, Emrich HM, Raptis C, Pirke KM: Effect of in vivo lithium treatment on (-)isoproterenol-stimulated cAMP accumulation in lymphocytes of healthy subjects and patients with affective psychoses. Pharmacopsychiatry 1989; 22: 241–245.

    Google Scholar 

  • Loosen PT, Prange Jr AJ: Serum thyrotopin response to thyrotropin-releasing hormone in psychiatric patients: A review. Am J Psychiatry 1982; 139: 405–416.

    PubMed  CAS  Google Scholar 

  • Lowndes JM, Hokin-Neaverson M, Bertics PJ: Kinetics of phosphorylation of Na+/K+-ATPase by protein kinase C. Biochim Biophys Acta 1990; 1052: 143–151.

    PubMed  CAS  Google Scholar 

  • Lu R-B, Ho S-L, Ho BT, Leu S-Y, Shian L-R, Chen W-L: Correlation between plasma cortisol and CSF catecholamines in endogenous depressed dexamethasone nonsuppressors. J Affect Disord 1986; 10: 177–184.

    PubMed  CAS  Google Scholar 

  • Maas JW, Koslow SH, Katz MM, Bowden CL, Gibbons RL, Stokes PE, Robins E, Davis JM: Pretreatment neurotransmitter metabolite levels and response to tricyclic antidepressant drugs. Am J Psychiatry 1984; 141: 1159–1171.

    PubMed  CAS  Google Scholar 

  • Maas JW, Koslow SH, Davis JM, Katz MM, Frazer A, Bowden CL, Berman N, Gibbons R, Stokes P, Landis H: Catecholamine metabolism and disposition in healthy and depressed subjects. Arch Gen Psychiatry 1987; 44: 337–344.

    PubMed  CAS  Google Scholar 

  • Manier DH, Gillespie DD, Sanders-Bush E, Sulser F: The serotonin/noradrenaline link in brain. I. The role of noradrenaline and serotonin in the regulation of density and function of ß adrenoceptors and its alteration by desipramine. Naunyn-Schmiedeberg’s Arch Pharmacol 1987; 335: 109–114.

    PubMed  CAS  Google Scholar 

  • Martin JV, Edwards E, Johnson JO, Henn FA: Monamine receptors in an animal model of affective disorder. J Neurochem 1990; 55: 1142–1148.

    PubMed  CAS  Google Scholar 

  • Mathew RJ, Wilson WH: Anxiety and cerebral blood flow. Am J Psychiatry 1990; 147: 838–849.

    PubMed  CAS  Google Scholar 

  • McNamara J: Role of neurotransmitters in seizure mechanisms in the kindling model of epilepsy. Fed Proc 1984; 43: 2516–2520.

    PubMed  CAS  Google Scholar 

  • Meltzer HL: Lithium mechanisms in bipolar illness and altered intracellular calcium function. Biol Psychiatry 1987; 21: 492–510.

    Google Scholar 

  • Meltzer HL, Kassir S, Goodnick PJ, Fieve RR, Chrisomalis L, Feliciano M, Szypula D: Calmodulin-activated calcium ATPase in bipolar illness. Neuropsychobiology 1988; 20: 169–173.

    PubMed  CAS  Google Scholar 

  • Meltzer HY, Umberkoman-Wiita B, Robertson A, Tricou BJ, Lowy M, Perline R: Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders: I. Enhanced response in depression and mania. Arch Gen Psychiatry 1984; 41: 366–374.

    PubMed  CAS  Google Scholar 

  • Menkes DB, Rasenick MM, Wheeler MA, Bitensky MW: Guanosine triphosphate activation of brain adenylate cyclase: Enhancement by long-term antidepressant treatment. Science 1983; 219: 65–67.

    PubMed  CAS  Google Scholar 

  • Miller BL, Lin K-M, Djenderedjian A, Tang C, Hill E, Fu P, Nuccio C, Jenden DJ: Changes in red blood cell choline and choline-bound lipids with oral lithium. Experientia 1989; 46: 454–456.

    Google Scholar 

  • Modai I, Zemishlany Z, Jerushalmy Z: 5-hydroxytryptamine uptake by blood platelets of unipolar and bipolar depressive patients. Neuropsychobiology 1985; 12: 93–95.

    Google Scholar 

  • Morrisett RA, Chow C, Nadler JV, McNamara JO: Biochemical evidence for enhanced sensitivity to N-methyl-D-asparate in the hippocampal formation of kindled rats. Brain Res 1989; 496: 25–28.

    PubMed  CAS  Google Scholar 

  • Nakajima T, Laval J-L, Gleiter CH, Deckert J, Post RM, Marangos PJ: C-fos mRNA expression following electrical-induced seizure and acute nociceptive stress in mouse brain. Epilepsy Res 1989; 4: 156–159.

    PubMed  CAS  Google Scholar 

  • Naylor GJ, Smith AHW: Defective genetic control of sodium pump density in manic-depression patients. Psychol Med 1981; 11: 257–263.

    PubMed  CAS  Google Scholar 

  • Nurnberger Jr J, Jimerson DC, Allen JR, Simmons S, Gershon E: Red cell ouabain-sensitive Na+-K+-Adenosine triphosphatase: A state marker in affective disorder inversely related to plasma cortisol. Biol Psychiatry 1982; 17: 981–992.

    PubMed  CAS  Google Scholar 

  • Nurnberger Jr J, Berrettini W, Mendelson W, Sack D, Gershon ES: Measuring cholinergic sensitivity: I. Arecoline effects in bipolar patients. Biol Psychiatry 1989; 25: 610–617.

    PubMed  Google Scholar 

  • Nurnberger Jr JI, Berrettini WH, Simmons-Alling S, Lawrence D, Brittain H: Blunted ACTH and cortisol response to afternoon tryptophan infusion in euthymic bipolar patients. Psychiatry Res 1990; 31: 57–67.

    PubMed  CAS  Google Scholar 

  • O’Flaherty JT: Phospholipid mechanism and stimulus-response coupling. Biochem Pha rmacol 1987; 36: 407–412.

    Google Scholar 

  • Okada K, Oishi R, Saeki K: Inhibition by antimanic drugs of hyperactivity induced by methamphetamine-chlordiazepoxide mixture in mice. Pharmacol Biochem Behav 1990; 35: 897–901.

    PubMed  CAS  Google Scholar 

  • Osman OT, Rudorfer MV, Potter WZ: Idazoxan: A selective a-2 antagonist and effective sustained antidepressant in two bipolar depressed patients. Arch Gen Psychiatry 1989; 46: 958–959.

    PubMed  CAS  Google Scholar 

  • Pandey GN, Pandey SC, Janicak PG, Marks RC, Davis JM: Platelet serotonin-2 receptor binding sites in depression and suicide. Biol Psychiatry 1990; 28: 215–222.

    PubMed  CAS  Google Scholar 

  • Piletz JE, Schubert DSP, Halaris A: Evaluation of studies on platelet alpha2 adrenoreceptors in depressive illness. Life Sci 1986; 39: 1589–1616.

    PubMed  CAS  Google Scholar 

  • Post RM: Sensitization and kindling perspectives for the course of affective illness: Toward a new treatment with the anticonvulsant carbamazepine. Pharmacopsychiatry 1990; 23: 3–17.

    PubMed  CAS  Google Scholar 

  • Post RM, Stoddard FJ, Gillin JC, Buchsbaum MS, Runkle DC, Black KE, Bunney Jr WE: Alterations in motor activity, sleep, and biochemistry in a cycling manic-depressive patient. Arch Gen Psychiatry 1977; 34: 470–477.

    PubMed  CAS  Google Scholar 

  • Post RM, Rubinow DR, Ballenger JC: Conditioning and sensitization in the longitudinal course of affective illness. Br J Psychiatry 1986; 149: 191–201.

    PubMed  CAS  Google Scholar 

  • Post RM, Weiss SRB, Pert A, Uhde TW: Chronic cocaine administration: Sensitization and kindling effects. In: Fisher S. (Ed.), Cocaine: Clinical and Biobehavioral Aspects. New York: Oxford University Press, 1987.

    Google Scholar 

  • Post RM, Rubinow DR, Uhde TW, Roy-Byrne PP, Linnoila M, Rosoff A, Cowdry R: Dysphoric mania: Clinical and biological correlates. Arch Gen Psychiatry 1989; 46: 353–358.

    PubMed  CAS  Google Scholar 

  • Prange Jr AJ, Wilson JC, Lynn CW, Alltop LB, Stikeleather RA: L-tryptophan in mania: Contribution to a permissive amine hypothesis of affective disorders. Arch Gen Psychiatry 1974; 30: 56–62.

    PubMed  Google Scholar 

  • Price LH, Charney DS, Heninger GR: Three cases of manic symptoms following yohimbine administration. Am J Psychiatry 1984; 141: 1267–1268.

    PubMed  CAS  Google Scholar 

  • Price LH, Charney DS, Delgado PL, Heninger GR: Lithium treatment and serotoninergic function. Neuroendocrine and behavioral responses to intravenous tryptophan in affective disorder. Arch Gen Psychiatry 1989; 46: 13–19.

    PubMed  CAS  Google Scholar 

  • Price LH, Charney DS, Delgado PL, Goodman WK, Krystal JH, Woods S, Heninger GR: Clinical studies of 5-HT function using I.V. L-tryptophan. Prog Neuropsychopharmacol Biol Psychiatry 1990; 14: 459–472.

    PubMed  CAS  Google Scholar 

  • Quintana Q: Platelet imipramine binding in endogenous depressed patients and controls: Relationship to platelet MAO and 5HT uptake during successful imipramine treatment. Psychiat Res 1990; 33: 229–242.

    CAS  Google Scholar 

  • Reddy PL, Khanna S, Subhash MN, Channabasavanna SM, Rao BSSR: Erythrocyte membrane Na-K ATPase activity in affective disorder. Biol Psychiatry 1989; 26: 533–537.

    PubMed  CAS  Google Scholar 

  • Roy A, De Jong J, Linnoila M: Cerebrospinal fluid monoamine metabolites and suicidal behavior in depressed patients. A 5-year follow-up study. Arch Gen Psychiatry 1989; 46: 609–612.

    PubMed  CAS  Google Scholar 

  • Roy A, De Jong J, Linnoila M: Extraversion in pathological gamblers: Correlates with indexes of noradrenergic function. Arch Gen Psychiatry 1989; 46: 679–681.

    PubMed  CAS  Google Scholar 

  • Rubin AL, Price LH, Charney DS, Heninger GR: Noradrenergic function and the cortisol response to dexamethasone in depression. Psychiatry Res 1985; 15: 5–15.

    PubMed  CAS  Google Scholar 

  • Rybakowski JK, Amsterdam JD, Dyson WL, Winokur A, Kurtz J: Factors contributing to erythrocyte lithium-sodium countertransport activity in lithium-treated bipolar patients. Pharmacopsychiatry 1989; 22: 16–20.

    PubMed  CAS  Google Scholar 

  • Schasfoort EMC, De Bruin LA, Korf J: Mild stress stimulates rat hippocampal glucose utilization transiently via NMDA receptors as assessed by lactography. Brain Res 1988; 475: 58–63.

    PubMed  CAS  Google Scholar 

  • Schatzberg AF, Samson JA, Bloomingdale KL, Orsulak PJ, Gerson B, Kizuka PP, Cole JO, Schildkraut JJ: Toward a biochemical classification of depressive disorders. X. Urinary catecholamines, their metabolites, and D-type scores in subgroups of depressive disorders. Arch Gen Psychiatry 1989; 46: 260–268.

    PubMed  CAS  Google Scholar 

  • Schwitzer J, Neudorfer C, Blecha H-G, Fleishhacker WW: Mania as a side effect of phototherapy. Biol Psychiatry 1990; 28: 532–534.

    PubMed  CAS  Google Scholar 

  • Sclare P, Creed F: Life events and the onset of mania. Br J Psychiatry 1990; 156: 508–514.

    PubMed  CAS  Google Scholar 

  • Shin C, McNamara JO, Morgan JI, Curran T, Cohen D: Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats. J Neurochem 1990; 55: 1050–1055.

    PubMed  CAS  Google Scholar 

  • Shopsin B, Janowsky DS, Davis JM, Gershon S: Rebound phenomena in manic patients following physostigmine. Neuropsychobiology 1969; 1: 180–187.

    Google Scholar 

  • Silberman EK, Reus VI, Jimerson DC, Lynott AM, Post RM: Heterogeneity of amphetamine response in depressed patients. Am J Psychiatry 1981; 138: 1302–1307.

    PubMed  CAS  Google Scholar 

  • Silfverskjold P, Risberg J: Regional cerebral blood flow in depression and mania. Arch Gen Psychiatry 1989; 46: 253–259.

    Google Scholar 

  • Silverstone T, Romans-Clarkson S: Bipolar affective disorder: Causes and prevention of relapse. Br J Psychiatry 1989; 154: 321–335..

    Google Scholar 

  • Sitaram N, Gillin JC, Bunney WE: Circadian effects on the time of switch, clinical ratings, and sleep in bipolar patients. Acta Psychiat Scand 1978; 58: 267–268.

    PubMed  CAS  Google Scholar 

  • Souetre E, Salvati E, Wehr TA, Sack DA, Krebs B, Darcourt G: Twenty-four hour profiles of body temperature and plasma TSH in bipolar patients during depression and during remission and in normal control subjects. Am J Psychiatry 1988; 145: 1133–1137.

    PubMed  CAS  Google Scholar 

  • Stahl WL: The Na,K-ATPase of nervous tissue. Neurochemistry 1986; 8: 449–476.

    CAS  Google Scholar 

  • Steketee JD, Striplin CD, Murray TF, Kalivas PW: Possible role for G-proteins in behavioral sensitization to cocaine. Brain Res 1991; 545: 287–291.

    PubMed  CAS  Google Scholar 

  • Stokes PE, Stoll PM, Koslow SH, Maas JW, Davis JM, Swann AC, Robins E: Pretreatment DST and hypothalamic-pituitary-adrenocortical function in depressed patients and comparison groups. Arch Gen Psychiatry 1984; 41: 257–267.

    PubMed  CAS  Google Scholar 

  • Stokes PE, Maas JW, Davis JM, Koslow SH, Casper RC, Stoll PM: Biogenic amine and metabolite levels in depressed patients with high versus normal hypothalamic-pituitary-adrenocortical activity. Am J Psychiatry 1987; 144: 868–872.

    PubMed  CAS  Google Scholar 

  • Stone EA: Adaptation to stress and brain noradrenergic receptors. Neurosci Biobehav Rev 1987; 7: 503–509.

    Google Scholar 

  • Stone EA: Central cyclic-AMP-linked noradrenergic receptors: New findings as related to the actions of stress. Neurosci Biobehav Rev 1987; 11: 391–398.

    PubMed  CAS  Google Scholar 

  • Stryzewski W, Rybakowski J, Potok E, Zelechowska-Ruda E: Erythrocyte cation transport in endogenous depression: Clinical and psychophysiological studies. Acta Psychiat Scand 1984; 70: 248–253.

    Google Scholar 

  • Swann AC: Thyroid hormone and norepinephrine: Effects on a-2, ß,and reuptake sites in cerebral cortex and heart. J Neural Trans 1988; 71: 195–205.

    Google Scholar 

  • Swann AC: Noradrenaline and thyroid function regulate (Na+,K+)-ATPase independently in vivo. Eur J Pharmacol 1989; 169: 275–283.

    Google Scholar 

  • Swann AC, Secunda S, Davis JM, Robins E, Hanin I, Koslow SH, Maas JW: CSF monoamine metabolites in mania. Am J Psychiatry 1983; 140: 396–400.

    Google Scholar 

  • Swann AC, Secunda SK, Katz MM, Maas JW, Chong S, Robins E: Lithium treatment of mania: Clinical characteristics, specificity of symptom change, and outcome. Psychiat Res 1986; 18: 127–141.

    Google Scholar 

  • Swann AC, Koslow SH, Katz MM, Maas JW, Javaid J, Secunda S, Robins E: Lithium carbonate treatment of mania: Cerebrospinal fluid and urinary monoamine metabolites and treatment outcome. Arch Gen Psychiatry 1987; 44: 345–354.

    Google Scholar 

  • Swann AC, Berman N, Frazer A, Koslow SH, Maas JW, Pandey GN, Secunda S: Lithium distribution in mania: Single-dose pharmacokinetics and sympathoadrenal function. Psychiat Res 1990; 32: 71–84.

    Google Scholar 

  • Swann AC, Secunda SK, Stokes PE, Croughan J, Davis JM, Koslow SH, Maas JW: Stress, depression, and mania: Relationship between perceived role of stressful events and clinical and biochemical characteristics. Acta Psychiat Scand 1990; 81: 389–397.

    Google Scholar 

  • Swayze II VW, Andreasen NC, Alliger RJ, Ehrhardt JC, Yuh WTC: Structural brain abnormalities in bipolar affective disorder. Ventricular enlargement and focal signal hyperintensities. Arch Gen Psychiatry 1990; 47: 1054–1059.

    Google Scholar 

  • Tan CH, Javors MA, Seleshi E, Lowrimore PA, Bowden CL: Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls. Life Sci 1990; 46: 1175–1180.

    Google Scholar 

  • Tanaka K, Gotoh F, Ishihara N, Gomi S, Takashima S, Mihara B: Autoradio-graphic analysis of second-messenger systems in the gerbil brain. Brain Res Bull 1988; 21: 693–700.

    Google Scholar 

  • Thase ME, Himmelhoch JM, Mallinger AG, Jarrett DB, Kupfer DJ: Sleep EEG and DST findings in anergic bipolar depression. Am J Psychiatry 1989; 146: 329–333.

    Google Scholar 

  • Turaihi MA, Khokher K, Barradas MA, Mikhalidis DP, Dandona P: 86Rb(K) influx and [3Hlouabain binding by human platelets: Evidence for ß-adrenergic stimulation of Na,K-ATPase activity. Metabolism 1989; 38: 773–776.

    Google Scholar 

  • Vadnal RE, Bazan NG: Carbamazepine inhibits electroconvulsive shock-elicited inositol triphosphate (IP3) accumulation in rat cerebral cortex and hippo-campus. Biochem Biophys Res Commun 1988; 153: 128–134.

    Google Scholar 

  • Vale AL, Ratcliffe F: Effect of lithium administration on rat brain 5-hydroxyindole levels in a possible animal model for mania. Psychopharmacology 1987; 91: 352–355.

    Google Scholar 

  • Voronin LL: Long-term potentiation in the hippocampus. Neuroscience 1983; 10: 1051–1069.

    PubMed  CAS  Google Scholar 

  • Wachtel H: The second-messenger dysbalance hypothesis of affective disorders. Pharmacopsychiatry 1990; 23: 27–32.

    PubMed  CAS  Google Scholar 

  • Waldmeier PC: Is there a common denominator for the antimanic effect of lithium and anticonvulsants? Pharmacopsychiatry 1987; 20: 37–47.

    PubMed  CAS  Google Scholar 

  • Wehr TA: Manipulations of sleep and phototherapy: Nonpharmacological alternatives in the treatment of depression. Clin Neuropharmacol 1990; 13: (Suppl 1): S54 - S65.

    PubMed  Google Scholar 

  • Wehr TA, Goodwin FK: Can antidepressants cause mania and worsen the course of affective illness? Am J Psychiatry 1987; 144: 1403–1411.

    PubMed  CAS  Google Scholar 

  • Wehr TA, Goodwin FK, Wirz-Justice A, Breitmaier J, Craig C: 48-hour sleep—wake cycles in manic—depressive illness: Naturalistic observations and sleep deprivation experiments. Arch Gen Psychiatry 1982; 39: 559–565.

    PubMed  CAS  Google Scholar 

  • Wehr TA, Sack DA, Rosenthal NE: Sleep reduction as a final common pathway in the genesis of mania. Am J Psychiatry 1987; 144: 201–204.

    PubMed  CAS  Google Scholar 

  • Wehr TA, Sack DA, Rosenthal NE, Cowdry RW: Rapid cycling affective disorder: Contributing factors and treatment responses in 51 cases. Am J Psychiatry 1988; 145: 179–184.

    PubMed  CAS  Google Scholar 

  • Weiss SRB, Post RM, Costello M, Nutt DJ, Tandiarz S: Carbamazepine retards the development of cocaine-kindled seizures but not sensitization to cocaine-induced hyperactivity. Neuropsychopharmacology 1990; 3: 273–281.

    PubMed  CAS  Google Scholar 

  • Werstiuk ES, Steiner M, Burns T: Studies on leukocyte ß-adrenergic receptors in depression: A critical appraisal. Life Sci 1990; 47: 85–105.

    PubMed  CAS  Google Scholar 

  • Weiss SRB, Post RM, Pert A, Woodward R, Murman D: Context-dependent cocaine sensitization: Differential effect of haloperidol on development versus expression. Pharmacol Biochem Behav 1989; 34: 665–661.

    Google Scholar 

  • Whalley LJ, Kutcher S, Blackwood DHR, Bennie J, Dick H, Fink G: Increased plasma LH in manic-depressive illness: Evidence of a state-independent abnormality. Br J Psychiatry 1987; 150: 682–684.

    PubMed  CAS  Google Scholar 

  • Whybrow P, Mendels J: Toward a biology of depression: Some suggestions from neurophysiology. Am J Psychiatry 1969; 125: 45–54.

    Google Scholar 

  • Wolpert EA, Goldberg JF, Harrow M: Rapid cycling in unipolar and bipolar affective disorders. Am J Psychiatry 1990; 147: 725–728.

    PubMed  CAS  Google Scholar 

  • Wood AJ, Elphick M, Aronson JK, Grahame-Smith DG: The effect of lithium on cation transport measured in vivo in patients suffering from bipolar affective illness. Br J Psychiatry 1989; 155: 504–510.

    PubMed  CAS  Google Scholar 

  • Wood AJ, Brearley CJ, Aronson JK, Grahame-Smith DG: The effect of oral salbutamol on cation transport measured in vivo in healthy volunteers. Br J Clin Pharmacol 1990; 30: 383–390.

    PubMed  CAS  Google Scholar 

  • Wood AJ, Smith CE, Clarke EE, Cowen PJ, Aronson JK, Grahame-Smith DG: Altered in vitro adaptive responses of lympocyte Nat, K+-ATPase in patients with manic—depressive psychosis. J Affect Disord 1991; 21: 199–206.

    PubMed  CAS  Google Scholar 

  • Yates M, Leake A, Candy JM, Fairbairn AF, McKeith IG, Ferrier IN: 5HT2 receptor changes in major depression. Biot Psychiatry 1990; 27: 489–496.

    CAS  Google Scholar 

  • Zawia NH, Bondy SC: Electrically stimulated rapid gene expression in the brain: Ornithine decarboxylase and c-fos. Mol Brain Res 1990; 7: 243–247.

    PubMed  CAS  Google Scholar 

  • Zis AP, Goodwin FK: Major affective disorder as a recurrent illness. A critical review. Arch Gen Psychiatry 1979; 36: 835–839.

    PubMed  CAS  Google Scholar 

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  1. Department of Psychiatry, University of Texas Medical School, Houston, Texas, 77030, USA

    Alan C. Swann

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Swann, A.C. (1993). Biology of Bipolar Disorder. In: Mann, J.J., Kupfer, D.J. (eds) Biology of Depressive Disorders. The Depressive Illness Series, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9501-1_1

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