The HPA Axis and Depressive Disorders

  • Roger F. Haskett
Part of the The Depressive Illness Series book series (DISS, volume 3)


During the past two decades, various abnormalities of hypothalamicpituitary-adrenocortical (HPA) axis function have been described in patients with depressive illness. Abnormalities were initially observed at the most peripheral level, i.e., urinary excretion of cortisol metabolites, but the development of reliable assays for the direct measurement of circulating hormones provided the impetus for an extensive progression of studies. Although the focus of investigation has undergone period reevaluation, the phenomenon of HPA axis dysregulation continues to intrigue investigators of the biology of depression and the “stress response.”


Depressed Patient Endogenous Depression Pituitary Peptide Chronic Corticosterone Treatment Sone Suppression Test 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Roger F. Haskett
    • 1
  1. 1.Department of PsychiatryUniversity of Pittsburgh School of Medicine, Western Psychiatric Institute and ClinicPittsburghUSA

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