Thyroid Axis and Depressive Disorders
Interest has been directed to the relationship between depressive disorders and thyroid axis function for many years. In the past 20 years, numerous studies have examined various indices of thyroid axis function in patients with depressive disorders and effects of thyroid axis hormones on mood and behavior. A third line of interest has involved effects of various psychotropic drugs used in the treatment of affective disorders on thyroid axis function. The major focus of this chapter will be on studies examining the interaction between the thyroid axis and depression. However, we start with a brief overview of reasons for interest in a role of the thyroid axis in depression.
KeywordsThyroid Hormone Depressed Patient Sleep Deprivation Ground Squirrel Thyrotropin Release Hormone
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- Bauer MS, Whybrow PC: Thyroid hormones and the central nervous system in affective illness: Interactions that may have clinical significance. Integr Psychiat 1988; 6: 75–100.Google Scholar
- Baumgartner A, Gräf KJ, Kürten I, Meinhold H: The hypothalamic-pituitarythyroid axis in psychiatric patients and healthy subjects. Part II. Repeated measurements of thyroxine, free thyroxine, triiodothyronine in patients with major depressive disorder and schizophrenia and healthy subjects. Psychiat Res. 1988; 24: 283–305.CrossRefGoogle Scholar
- Baumgartner A, Gräf KJ, Kürten I, Meinhold H, Scholz P: Neuroendocrinological investigations during sleep deprivation in depression. I. Early morning levels of thyroxine, TH cortisol, prolactin, LH. FSH, cortisol, prolactin, LH, FSH, estradiol and testosterone. Biol Psychiat 1990; 28: 556–558.PubMedCrossRefGoogle Scholar
- Breese GR, Cooper BR, Prange AJ, Cott JM, Lipton MA: Interactions of thyrotropin-releasing hormone with centrally action drugs. In: Prange AJ (Ed.), The Thyroid Axis, Drugs and Behavior, New York: Raven Press, 1974, 115–128.Google Scholar
- Breese GR, Prange AJ, Lipton MA: Pharmacological studies and thyroidimipramine interactions in animals. In: Prange AJ (Ed.), The Thyroid Axis, Drugs and Behavior, New York: Raven Press, 1974, 29–48.Google Scholar
- Dratman MB, Crutchfield FL, Gordon JT: Thyroid hormones and adrenergic neurotransmitter. In: Catecholamines, Neuropharmacology and Central Nervous System: Theoretical Aspects, New York: Alan R. Liss, 1984, 425–436.Google Scholar
- Everett GM: The DOPA response potentiation test and its use in screening for antidepressant drugs. Excerpta Med Int Congr Sery No. 122, 1966.Google Scholar
- Ford DH, Cramer EB: Developing nervous system in relation to thyroid hormones. In: Grave GD (Ed.), Thyroid Hormones and Brain Development, New York: Raven Press, 1977, 1–17.Google Scholar
- Manaker S, Winokur A, Rostene WH, Rainbow TC: Autoradiographic localization of thyrotropin releasing hormone (TRH) receptors in the rat CNS. J Nueurosci 1985; 35: 167–174.Google Scholar
- Schmidt BH, Schultz JE: Chronic thyroxine treatment of rats down-regulates the noradrenergic cyclic AMP generating system in cerebral cortex. J Pharmacol Exp Therapeut 1985; 233: 466–472.Google Scholar
- Sterling K: Thyroid hormone action at the cell level. New Eng J Med 1975; 300: 117–123, 173–177.Google Scholar
- Winokur A: The relevance of thyrotropin-releasing hormone to psychiatric disorders. In: Nemeroff CB (Ed.), Neuropeptides and Psychiatric Disorders, Washington, DC: American Psychiatric Press, 1990, 13–281.Google Scholar