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Gaba and Depression

  • Chapter
Biology of Depressive Disorders. Part A

Part of the book series: The Depressive Illness Series ((DISS,volume 3))

Abstract

From a historical perspective, the amino acid neurotransmitters are recent candidates for consideration in theories of psychiatric illness. The biogenic amines, particularly norepinephrine and serotonin, have traditionally played a major role in theories regarding the biochemical basis of depression and of its treatment. This is readily explained by a general focus in neuroscience on biogenic amine neurochemistry and neuropharmacology during the formative decades of biological psychiatry. Also, it reflects the early observation that depletion of the biogenic amines with agents such as reserpine was often accompanied by the development of depressive symptoms. Similarly, the first-generation antidepressants were early reported to enhance biogenic amine activity through inhibition of monoamine oxidase or blockade of synaptic reuptake. Thus the catecholamine theory of depression was first published about 25 years ago.

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Authors and Affiliations

  1. Veterans Affairs Medical Center and Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, Texas, 75216, USA

    Frederick Petty, Gerald L. Kramer & William Hendrickse

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  1. Frederick Petty
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  1. Laboratories of Neuropharmacology, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, 15213, Pittsburgh, Pennsylvania, USA

    J. John Mann M.D.

  2. Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 15213, Pittsburgh, Pennsylvania, USA

    David J. Kupfer M.D.

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Petty, F., Kramer, G.L., Hendrickse, W. (1993). Gaba and Depression. In: Mann, J.J., Kupfer, D.J. (eds) Biology of Depressive Disorders. Part A. The Depressive Illness Series, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9498-4_4

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