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Cholinergic Supersensitivity in Affective Disorders

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Biology of Depressive Disorders. Part A

Part of the book series: The Depressive Illness Series ((DISS,volume 3))

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Abstract

Disturbance of cholinergic regulation is implicated in the aetiology of affective disorders, with some indication that the defect may lie at the level of the central muscarinic cholinergic receptors. Although direct experimental evidence in support of this hypothesis is lacking because of the absence of an “ideal” model to study m-cholinoceptor sensitivity in psychiatric patients, there is a large body of indirect data that points toward a cholinergic supersensitivity in mood disorders. Some of the controversies in support of this theory may be better understood with the identification and cloning of the muscarinic cholinergic receptor subtypes (M1–M5), each with a unique pharmacological profile and distribution in different regions of the brain.

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  1. Mood Disorders Module, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, 15213, USA

    Sanjay Dubé

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  1. Laboratories of Neuropharmacology, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, 15213, Pittsburgh, Pennsylvania, USA

    J. John Mann M.D.

  2. Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 15213, Pittsburgh, Pennsylvania, USA

    David J. Kupfer M.D.

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Dubé, S. (1993). Cholinergic Supersensitivity in Affective Disorders. In: Mann, J.J., Kupfer, D.J. (eds) Biology of Depressive Disorders. Part A. The Depressive Illness Series, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9498-4_3

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