Cholinergic Supersensitivity in Affective Disorders

  • Sanjay Dubé
Part of the The Depressive Illness Series book series (DISS, volume 3)


Disturbance of cholinergic regulation is implicated in the aetiology of affective disorders, with some indication that the defect may lie at the level of the central muscarinic cholinergic receptors. Although direct experimental evidence in support of this hypothesis is lacking because of the absence of an “ideal” model to study m-cholinoceptor sensitivity in psychiatric patients, there is a large body of indirect data that points toward a cholinergic supersensitivity in mood disorders. Some of the controversies in support of this theory may be better understood with the identification and cloning of the muscarinic cholinergic receptor subtypes (M1–M5), each with a unique pharmacological profile and distribution in different regions of the brain.


Affective Disorder Muscarinic Receptor Muscarinic Cholinergic Receptor Cholinergic Mechanism Affective Illness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Sanjay Dubé
    • 1
  1. 1.Mood Disorders ModuleWestern Psychiatric Institute and ClinicPittsburghUSA

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