Evaluation of Blood-Brain Barrier Rupture in a Rat Glioma Model by Using a Contrast Agent for Magnetic Resonance Imaging

  • G. Le Duc
  • C. Rémy
  • M. Péoc’h
  • M. Décorps
  • J. F. Le Bas
Part of the Advances in Behavioral Biology book series (ABBI, volume 46)

Summary

Brain tumor visualization has been improved significantly by Magnetic Resonance Imaging (MRI).This work shows that Sinerem®, a superparamagnetic contrast agent can bring new information about rat brain tumor physiology, more particularly BBB permeability, neovascularization and edema. Sinereml® induces a strong hyposignal mainly in some central patches and in the periphery of the tumor, both corresponding to vessels. Furthermore, Sinerem® slowly diffuses from vessels to extravascular space due to BBB breakdown.

Keywords

Contrast Agent Caudate Nucleus Extravascular Space Masson Trichrom Contrast Agent Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

L’utilisation d’agents de contraste en IRM a considérablement amélioré le diagnostic des tumeurs cérébrales. Ce travail met en évidence les résultats obtenus à partir d’un agent de contraste superparamagnétique sur un modèle de gliome intracérébral chez le rat. Après injection de Sinerem®, les tumeurs présentent des tâches centrales et une couronne périphérique en hyposignal. Cet hyposignal prononcé semble correspondre d’abord aux vaisseaux puis aux zones de rupture de la B.H.E: l’agent de contraste diffuse alors depuis les vaisseaux vers l’espace extracellulaire.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Félix R., Schomer W., Laniado M. et al. Radiology (1985); 156: 681–688.PubMedGoogle Scholar
  2. 2.
    Chambon C., Clément O.. Le Blanche A. et al. Mag. Res. Imaging (1993); 11: 509–519.CrossRefGoogle Scholar
  3. 3.
    Weissleder R., Elizondo G., Wittenberg J. et al. Radiology (1990); 175: 489–493.PubMedGoogle Scholar
  4. 4.
    Kobayashi N., Allen N., Clendenon N., et al. J. Neurosurg (1980); 53: 808–815.PubMedCrossRefGoogle Scholar
  5. 5.
    Benabid A., Rémy C., Chauvin C. in Biology of Brain Tumors (1986). Printed in the Netherlands. Walkers M.D., Thomas D.G.T. (eds).Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • G. Le Duc
    • 1
  • C. Rémy
    • 1
  • M. Péoc’h
    • 2
  • M. Décorps
    • 1
  • J. F. Le Bas
    • 3
  1. 1.INSERM U438CHU A. MichallonGrenoble Cedex 9France
  2. 2.Laboratoire d’Anatomie PathologiqueCHU A. MichallonGrenoble Cedex 9France
  3. 3.Unité IRMCHU A. MichallonGrenoble Cedex 9France

Personalised recommendations