Extracellular Matrix Proteins in Cerebral Vessels in Chronic Hypertension

  • Sukriti Nag
  • Dan Kilty
  • Shruti Dev
Part of the Advances in Behavioral Biology book series (ABBI, volume 46)

Summary

This study demonstrates progressive mural thickening of cerebral arterioles in chronic hypertension due to medial hyperplasia and due to overexpression of extracellular matrix proteins such as laminin, collagen IV and fibronectin. These changes are most marked in the stage II and III permeability lesions in which mural deposition of serum proteins in arterioles also occur. Since overexpression of extracellular matrix proteins occurs in cerebral vessels in conditions unassociated with hypertension. it may represent a nonspecific adaptive response of cellular components of the vessel wall to a variety of stimuli.

Keywords

Extracellular Matrix Protein Cerebral Vessel Chronic Hypertension Hypertensive Encephalopathy Pial Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Notre étude montre que l’hypertension vasculaire chronique s’accompagne d’un épaississement de la paroi des artérioles cérébrales dû à une hyperplasie cellulaire de la media des vaisseaux ainsi qu’à une surexpression des proteines de la matrice extracellutaire tels que la laminine, le col lagene 4 et la fibronectine. Ces modifications de l’histologie des artérioles cérébrales sont plus marquées au cours des stades 2 et 3 du développement des lésions vasculaires accompagnant l’hypertension, au cours desquelles a aussi lieu le depôt des protéines sériques sur la paroi des artérioles. Néanmoins, la surexpression de certaines protéines de la matrice extracellulaire dans les vaisseaux cérébraux peut être observée dans des conditions indépendantes de l’hypertension, suggérant que ce phénomène pourrait découler d’une réaction cellulaire vasculaire non spécifique face à differents facteurs.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Sukriti Nag
    • 1
  • Dan Kilty
    • 1
  • Shruti Dev
    • 1
  1. 1.Division of NeuropathologyUniversity of Toronto The Playfair Neuroscience Research UnitCanada

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