Abstract
Several receptors for different vasoactive substances have been shown to be coupled to the microvascular adenylate cyclase and to increase the intraendothelial amount of cyclic AMP (Joó, 1986, 1992, 1993). As a consequence of elevated intraendothelial cyclic AMP, changes in permeability (Joó, 1972; Rubin et al. 1991), in endothelial growth and differentiation (Kempski et al. 1987), in nitric oxide and endothelin secretions (Durieu-Trautmann et al. 1993) and in a hyperpolarization-activated current carried by both Na+ and K+ ions (Janigro et al. 1994) have been reported. Elevations of cyclic AMP concentrations may be important in regulating the endothelial barrier in two-ways: (i) by narrowing the paracellular pathways for small molecular weight substances (Rubin et al. 1991), and (ii) activating the transendothelial transport for macromolecules (Joó, 1972). Recently, Grammas et al. (1994) found significantly elevated cAMP levels in microvessels from Alzheimer’s disease compared to nondemented elderly controls.
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References
Catalan, R.E., A.M. Martinez, M.D. Aragonés, and I. Fernandez (1989) Substance P stimulates translocation of protein kinase C in brain microvessels. Biochem.Biophys.Res.Commun. 164: 595–600.
Deli, M., M.-P. Dehouck, R. Cecchelli, C.S. Abraham, and F. Joó (1995) Histamine induces a selective albumin permeation through the blood-brain barrier in vitro. Inflammation Res. 44: S56 - S57.
Deli, M., F. Joó, I. Krizbai, I. Lengyel, M.G. Nunzi, and J.R. Wolff (1993) Calcium/calmodulin-stimulated protein kinase II is present in primary cultures of cerebral endothelial cells. J.Neurochem. 60: 1960–1963.
Dóczi, T., F. Joó, P. Szerdahelyi, and M. Bodosi (1987) Regulation of brain water and electrolyte contents: the possible involvement of central atrial natriuretic factor. Neurosurgery 21: 454–458.
Drewes, L.R., M.A. Broderius, and D.Z. Gerhart (1988) Phorbol ester stimulates hexose uptake by brain microvessel endothelial cells. Brain Res.Bull. 21: 771–776.
Durieu-Trautmann, O., C. Fédérici, C. Créminon, N. Foignant-Chaverot, F. Roux, M. Claire, A.D. Strosberg, and P.O. Couraud (1993) Nitric oxide and endothelin secretion by brain microvessel endothelial cells: Regulation by cyclic nucleotides. J. Cellular Physiol. 155: 104–111.
Dux, E. and F. Joó (1982) Effects of histamine on brain capillaries: fine structural and immunohistochemical studies after intracarotid infusion. Exptl.Brain Res. 47: 252–258.
Dux, E., P. Temesvari, F. Joó, G. Adam, F. Clementi, L. Dux, J. Hideg, and K.A. Hossmann (1984) The blood-brain barrier in hypoxia: ultrastructural aspects and adenylate cyclase activity of brain capillaries. Neuroscience 12: 951–958.
Dux, E., P. Temesvari, P. Szerdahelyi, A. Nagy, J. Kovacs, and F. Joó (1987) Protective effect of antihistamines on cerebral oedema induced by experimental pneumothorax in newborn piglets. Neuroscience 22: 317–321.
Ehrlich, P. (1885) Das Sauerstoff-bedürfnis des Organismus. Eine farbenanalytische Studie.
Berlin: A. Hirschwald. Grammas, P., A.E. Roller, and M.J. Ball (1994) Increased accumulation of cAMPin cerebral microvessels in Alzheimer disease. Neurobiol. of Aging 15: 113–116.
Guillot, F.L., K.L. Audus, and T.J. Raub (1990) Fluid-phase endocytosis by primary cultures of bovine brain microvessel endothelial cell monolayers. Microvasc.Res. 39: 1–14.
Homayoun, P., W.D. Lust, and S.I. Harik (1989) Effect of several vasoactive agents on guanylate cyclase activity in isolated rat brain microvessels. Neurosci.Lett. 107: 273–278.
Huszti, Z., M.A. Deli, and F. Joó (1995) Carrier-mediated uptake and release of histamine by cultured rat cerebral endothelial cells. Neurosci. Letters 184: 185–188.
Ibaragi, M., M. Niwa, and M. Ozaki (1989) Atrial natriuretic peptide modulates amiloride-sensitive Na+ transport across the blood-brain barrier. J.Neurochem. 53: 1802–1806.
Janigro, D., G.A. West, T.-S. Nguyen, and H.R. Winn (1994) Regulation of blood-brain barrier endothelial cells by nitric oxyde. Circ. Res. 75: 528–538.
Joó, F. (1972) Effect of N6,06-dibutyril cyclic 3’,5’-adenosine monophosphate on the pinocytosis of brain capillaries in mice. Experientia 28: 1470–1471.
Joó, F. (1986) New aspects to the function of cerebral endothelium. Nature 321: 197–198.
Joó, F. (1992) The cerebral microvessels in tissue culture. an update. J.Neurochem. 58: 1–17.
Joó, F. (1993) The blood-brain barrier in vitro: The second decade. Neurochem. Int. 23: 499–521.
Joó, F. and I. Klatzo (1989) Role of cerebral endothelium in brain oedema. Neurol.Res. 11: 67–75.
Karnushina, I.L., J.M. Palacios, G. Barbin, E. Dux, F. Joó, and J.C. Schwartz (1980) Studies on a capillary-rich fraction isolated from brain: histaminic components and characterization of the histamine receptors linked to adenylate cyclase. J.Neurochem. 34: 1201–1208.
Kempski, O., B. Wroblewska, and M. Spatz (1987) Effects of forskolin on growth and morphology of cultured glial and cerebrovascular endothelial and smooth muscle cells. Int.J.Dev.Neurosci. 5: 435–445.
Krizbai, I., G. Szabó, M. Deli, K. Maderspach, C. Lehel, Z. Olah, J.R. Wolff, and F. Joó (1995) Expression of protein kinase C family members in the cerebral endothelial cells. J. Neurochem. 65: 495–462.
Lane, T.A., G.E. Lamkin, and E. Wancewicz (1989) Modulation of endothelial cell expression of intracellular adhesion molecule 1 by protein kinase C activation. Biochem.Biophys.Res.Commun. 161: 945–952.
Markovac, J. and G.W. Goldstein (1988) Transforming growth factor beta activiates protein kinase C in microvessels isolated from immature rat brain. Biochem.Biophys.Res.Commun. 150: 575–582.
Marsault, R. and C. Frelin (1992) Activation by nitric oxyde of guanylate cyclase in endothelial cells from brain capillaies. J.Neurochem. 59: 942–945.
Palmer, G.C. (1981) Distribution of guanylate cyclase in rat cerebral cortex: neuronal, glial, capillary, pia-arachnoid and synaptosomal fractions plus choroid plexus. Neuroscience 6: 2547–2553.
Revest, P.A., N.J. Abbott, and J.I. Gillespie (1991) Receptor mediated changes in intracellular Cat’ in cultured rat brain capillary endothelial cells. Brain Res. 549: 159–161.
Rubin, L.L., D.E. Hall, S. Porter, K. Barbu, C. Cannon, H.C. Homer, M. Janatpour, C.W. Liaw, K. Manning, J. Morales, L.I. Tanner, J. Tomaselli, and F. Bard (1991) A cell culture model of the blood-brain barrier. J.Cell.Biol. 115: 1725–1735.
Tdsaki, A., P. Szerdahelyi, and F. Joó (1994) Treatment with ranitidine of ischemic brain edema. Eur.J.Pharm. 264: 455–458.
Vigne, P., L. Lund, and C. Frelin (1994) Cross talk among cyclic AMP, cyclic GMP, and Ca2+-dependent intracellular signalling mechanisms in brain capillary endothelial cells. J. Neurochem. 62: 2269–2274.
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Joó, F. (1996). Significance of the Second Messenger Molecules in the Regulation of Cerebral Endothelial Cell Functions. In: Couraud, PO., Scherman, D. (eds) Biology and Physiology of the Blood-Brain Barrier. Advances in Behavioral Biology, vol 46. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9489-2_35
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DOI: https://doi.org/10.1007/978-1-4757-9489-2_35
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