The Permeability of Boronophenylalanine

A Compound Used for the Treatment of Cerebral Gliomas
  • H. Patel
  • J. W. Hopewell
Part of the Advances in Behavioral Biology book series (ABBI, volume 46)

Summary

The integrity of the blood-brain barrier may severely restrict the passage of drugs intended for cells within the central nervous system. These experiments were designed to show whether one particular drug used for the treatment of gliomas, boronophenylalanine (BPA), is affected by the state of the BBB.

The results show that the degree of BBB disruption does not influence the amount of BPA accumulating in normal brain tissue.

Keywords

Inductively Couple Plasma Mass Spectrometry Boron Atom Normal Brain Tissue Boron Neutron Capture Therapy Post Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

L’absence de perméabilité membranaire de la barrière hémato-encéphalique (BHE) peut restreindre gravement le passage de dérivés thérapeutiques destinés à traiter les cellules contenues dans le SNC. Cette étude a pour but de vérifier si l’action d’un dérivé particulier, utilisé pour le traitement des gliomes, la boronophénylalanine (BPA), est affectée par l’état de la BHE. Les résultats montrent que le degré de rupture de la BHE ne modifie pas la quantité de BPA accumulée dans les tissus normaux du cerveau.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • H. Patel
    • 1
  • J. W. Hopewell
    • 2
  1. 1.Clinical Neurological SciencesSouthampton General HospitalSouthamptonUK
  2. 2.Research InstituteChurchill HospitalOxfordUK

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