Prospects for Neuroprotective Gene Therapy for Neurodegenerative Diseases

  • Marc Peschanski
Part of the Advances in Behavioral Biology book series (ABBI, volume 46)


Neurodegenerative diseases are still, except for a few of them like Parkinson’s disease, out of reach of available therapeutics. Several breakthroughs in the past ten years have, however, opened new potential ways that are actively explored in a large number of laboratories. Two of these major advances that could be of therapeutic value are the discovery of several families of substances that are able to exert neuroprotective effects on the one hand, development of gene engineering techniques on the other hand. In our laboratory, a series of studies are ongoing to design ways, using these engineering techniques, to create biological minipumps able to secrete neuroprotective agents into the brain.


Amyotrophic Lateral Sclerosis Adenovirus Vector Embryonal Carcinoma Neuroprotective Agent Exogenous Gene 
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  1. Akli S, Caillaud C, Vigne E, Stratford-Perricaudet Ld, Poenaru L, Perricaudet M, Kahn A, Peschanski M. Transfer of foreign genes into the brain using adenovirus vectors. Nature Genetics_1993, 3: 224–225.Google Scholar
  2. Lisovoski F, Cadusseau J, Akli S, Caillaud C. Vigne E, Poenaru L, Stratford-Perricaudet L, Perricaudet M, Kahn A, Peschanski M. In vivo transfer of a marker gene to study motoneuronal development. Neuroreport, 1994, 5: 1069–1072PubMedCrossRefGoogle Scholar
  3. Wojcik B, Nothias F, Lazar M, Jouin H, Nicolas JE Peschanski M. Catecholaminergic neurons derived from intracerebral implantation of embryonal carcinoma cells. Proc Natl Acad Sci (USA), 1993, 90: 1305 1309.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Marc Peschanski
    • 1
  1. 1.INSERM U421, IM3Faculté de Médecine CréteilFrance

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