The Microarchitecture of Cerebral Vessels

  • Kenneth R. Davies
  • Grace Richardson
  • Wendy Akmentin
  • Virgil Acuff
  • Joseph D. Fenstermacher
Part of the Advances in Behavioral Biology book series (ABBI, volume 46)

Abstract

The morphology of microvascular systems within the brain is routinely studied in two dimensions using light microscopy or transmission electron microscopy. Limited to height and width, the flat images generated by these techniques lack the depth necessary to visualize the complete architecture of cerebral microvascular beds. To sculpture a “truer” representation, we integrated multiple-sequential, two-dimensional microscopic pictures to reconstruct a three-dimensional image of the microvascular network of the cerebral cortex and hippocampus.

Keywords

Cerebral Vessel Capillary Length Postcapillary Venule Micron Thick Section Microvascular System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bereczki D, Wei L, Acuff V, Gruber K, Tajima A, Patlak C, Fenstermacher J (1992) Technique-dependent variations in cerebral microvessel blood volumes and hematocrits in the rat. Journal ofApplied Physiology 73 (3): 918–924Google Scholar
  2. 2.
    Colin A (1939) Variation in Vascularity and Oxidase Content in Differnet Regions of the Brain of the Cat. Archives of Neurology and Psychiatry 41 (2): 223–242CrossRefGoogle Scholar
  3. 3.
    Duvernoy H, Delon S, Vannson J (1981) Cortical Blood Vessels of the Human Brain. Brain Research Bulletin 7: 519–579PubMedCrossRefGoogle Scholar
  4. 4.
    Gesztelyi G, Finnegan W, DeMaro JA, Wang JY, Chen JL, Fenstermacher J (1993) Parenchymal microvascular systems and cerebral atrophy in spontaneously hypertensive rats. Brain Research 611: 249–257PubMedCrossRefGoogle Scholar
  5. 5.
    Hertz M, Paulson 0 (1980) Heterogeneity of Cerebral Capillary Flow in Man and Its Consequences for Estimation of Blood-Brain Permeability. J. Clin. Invest. 65: 1145–1151Google Scholar
  6. 6.
    Hudetz A, Greene A, Feher G, Knuese D, Cowley A (1993) Imaging System for Three-Dimensional Mapping of Cerebrocortical Capillary Networks in Vivo. Microvascular Research 46: 293–309PubMedCrossRefGoogle Scholar
  7. 7.
    Hudetz A, Feher G, Weigle G, Knuese D, Kampine J (1995) Video microscopy of cerebrocortical capillary flow: response to hypotension and intracranial hypertension. American Journal of Physiology 268: H2202–2210PubMedGoogle Scholar
  8. 8.
    Lin S, Sposito N, Pettersen S, Rybacki L, McKenna E, Pettigrew K, Fenstermacher J (1990) Cerebral Capillary Bed Structure of Normotensive and Chronically Hypertensive Rats. Microvascular Research 40: 341–357PubMedCrossRefGoogle Scholar
  9. 9.
    Motti E, Imhof H, Yasargil M (1986) The terminal vascular bed in the superfacial cortex of the rat. An SEM study of corrosion casts. Journal of Neurosurgery 65: 834–846PubMedCrossRefGoogle Scholar
  10. 10.
    Pawlik G. Rackl A, Bing RJ (1981) Quantitative Capillary Topography and Blood Flow in the cerebral Cortex of Cats: An in vivo Microscopy Study. Brain Research 208: 35–58Google Scholar
  11. 11.
    Wei L, Lin S, Tajima A, Nakata H, Acuff V, Patlak C, Pettigrew K, Fenstermacher J (1992) Cerebral Glucose Utilization and Blood Flow in Adult Spontaneously Hypertensive Rats. Hypertension 20(4):501510Google Scholar
  12. 12.
    Yoshida Y, Ikuta F (1984) Three-Dimensional Architecture of Cerebral Microvessels with a Scanning Electron Microscope: A Cerebrovascular Casting Method for Fetal and Adult Rats. Journal of Cerebral Blood Flow and Metabolism 4: 290–296PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Kenneth R. Davies
    • 1
    • 2
  • Grace Richardson
    • 1
    • 2
  • Wendy Akmentin
    • 1
    • 2
  • Virgil Acuff
    • 1
    • 2
  • Joseph D. Fenstermacher
    • 1
    • 2
  1. 1.Department of AnesthesiaHenry Ford HospitalDetroitUSA
  2. 2.Department of NeurosurgeryState University of New YorkStony BrookUSA

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