Astroglia: Receptors, Second Messengers, and Function

  • M. O. Kristian Enkvist
  • Yanping Shao
  • Ken D. McCarthy
Part of the Altschul Symposia Series book series (ALSS, volume 2)


Research from a large number of laboratories has demonstrated that astroglia (GFAP positive cells in primary culture) exhibit a wide variety of neuroligand receptors (Cornell-Bell and Finkbeiner, 1991; Wilkin et al., 1990; Murphy and Pearce, 1987). Furthermore, it is evident that collectively these different astroglial receptor systems regulate most, if not all, of the known second messenger systems and that activation of these systems influences many different intracellular processes (Cummins et al., 1983; Hauser et al., 1990; Furukawa et al., 1987; Martin et al., 1988). While a large body of information has accumulated over the past two decades concerning the properties of astroglia, far less progress has been made toward understanding how these properties participate in brain physiology (ie. what is the function of astrocytes in brain?). The lack of information in this arena stems primarily from the absence of model systems whereby astrocytes can be studied in situ. However, information obtained using in vitro systems continues to provide important insight into the potential role of astrocytes in brain.


Astroglial Cell Calcium Wave Lucifer Yellow Receptor Autoradiography Aluminum Fluoride 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • M. O. Kristian Enkvist
    • 1
  • Yanping Shao
    • 1
  • Ken D. McCarthy
    • 1
  1. 1.Department of PharmacologyUniversity of North Carolina at Chapel HillChapel HillUSA

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