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Production of Nitrosyl Mediators in Astrocytes

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Part of the book series: Altschul Symposia Series ((ALSS,volume 2))

Abstract

Astroglial cells have the potential to play a dynamic role in intercellular communication in the CNS. These cells display a variety of surface receptors and have been shown to release a number of vaso- and neuroactive compounds (Murphy, 1993). The close spatial relationships of astrocytes with neurons, and with the microvasculature, implicates them in bidirectional signalling processes.

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References

  • Agullo, L., and Garcia, A., 1991, Norepinephrine increases cyclic GMP in astrocytes by a mechanism dependent on nitric oxide synthesis, Eur. J. Pharmacol. 206: 343.

    Article  PubMed  CAS  Google Scholar 

  • Agullo L., and Garcia A., 1992, Different receptors mediate stimulation of nitric oxide-dependent cyclic GMP formation in neurons and astrocytes in culture, Biochem. Biophys. Res. Commun. 182: 1362.

    Article  PubMed  CAS  Google Scholar 

  • Aoki E., Semba R., Mikoshiba K., and Kashiwamata S., 1991, Predominant localization in glial cells of free L-arginine. Immunocytochemical evidence, Brain Res. 547: 190.

    Article  PubMed  CAS  Google Scholar 

  • Benveniste, E.N., 1993, Astrocyte-microglia interactions, in: “Astrocytes: Pharmacology and Function,” S. Murphy, ed., Academic Press, San Diego.

    Google Scholar 

  • Bredt D.S., Hwang P.M., and Snyder S.H., 1990, Localization of nitric oxide synthase indicating a neural role for nitric oxide, Nature 347: 768.

    Article  PubMed  CAS  Google Scholar 

  • Bredt D.S., Hwang P.M., Glatt C.E., Lowenstein C., Reed R.R., and Snyder S.H., 1991, Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase, Nature 351: 714.

    Article  PubMed  CAS  Google Scholar 

  • Dawson, T.M., Bredt, D.S., Fotuhi, M., Hwang, P.M., and Snyder, S.H., 1991, Nitric oxide synthase and neuronal NADPH are identical in brain and peripheral tissues, Proc. Natl. Acad. Sci. 88: 7797.

    Article  PubMed  CAS  Google Scholar 

  • Forstermann, U., Schmidt, H.H.H.W., Pollock, J.S., Sheng, H., Mitchell, J.A., Warner, T.D., Nakane, M., and Murad, F., 1991, Isoforms of nitric oxide synthase, Biochem. Pharmacol. 42: 1849.

    Google Scholar 

  • Garthwaite, J., 1991, Glutamate, nitric oxide and cell-cell signalling in the nervous system, Trends Neurosci. 14: 60.

    Article  PubMed  CAS  Google Scholar 

  • Gross, S.S., Jaffe, E.A.,Levi, R., and Kilboum, R.G., 1991, Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages, Biochem. Biophys. Res. Comm. 178: 823.

    CAS  Google Scholar 

  • Lyons, C.R., Orloff, G.J., and Cunningham, J.M., 1992, Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line, J. Biol. Chem. 267: 6370.

    PubMed  CAS  Google Scholar 

  • McCall, T.B., Palmer R.M.J., and Moncada, S., 1991, Induction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone, Eur. J. Immunol. 21: 2523.

    Article  PubMed  CAS  Google Scholar 

  • Moncada, S., Palmer, R.M., and Higgs E.A., 1991, Nitric oxide: physiology, pathophysiology, and pharmacology, Pharm. Rev. 43: 109.

    PubMed  CAS  Google Scholar 

  • Murphy, S., 1993, “Astrocytes: Pharmacology and Function”, Academic Press, San Diego.

    Google Scholar 

  • Murphy, S., Minor R.L., Welk, G., and Harrison D.G., 1990, Evidence for an astrocyte-derived vasorelaxing factor with properties similar to nitric oxide, J. Neurochem. 55: 349.

    Article  PubMed  CAS  Google Scholar 

  • Murphy, S., Minor R.L., Welk G., and Harrison D.G., 1991, Central nervous system astroglial cells release nitrogen oxide(s) with vasorelaxant properties, J. Cardovasc. Pharmacol. 17: S265.

    Article  CAS  Google Scholar 

  • Salter, M., Knowles, R.G., and Moncada, S.,1991, Widespread tissue distribution, species distribution and changes in activity of Ca2+-dependent and Ca2+-independent nitric oxide synthases, FEBS Lett. 291: 145.

    Google Scholar 

  • Simmons, M.L., and Murphy, S., 1992, Induction of a nitric oxide synthase in glial cells, J. Neurochem. 59: 897.

    Article  PubMed  CAS  Google Scholar 

  • Stuehr D.J., and Nathan C.F., 1989, Nitric oxide: A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells, J. Exp. Med. 169: 1543.

    Article  PubMed  CAS  Google Scholar 

  • Xie, Q.W., Cho, H., Calaycay, J., Mumford, R., Swiderek, K., Lee, T.,Ding, A., Troso, T., and Nathan, C.,1992, Cloning and characterization of inducible nitric oxide synthase from mouse macrophages, Science 256: 225.

    Google Scholar 

  • Zielasek, J., Tausch M., Toyka, K.V., and Hartung, H.-P., 1992, Production of nitrite by neonatal rat microglial cells/brain macrophages, Cell. Immunol. 141: 111.

    Article  PubMed  CAS  Google Scholar 

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© 1993 Springer Science+Business Media New York

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Murphy, S., Simmons, M.L. (1993). Production of Nitrosyl Mediators in Astrocytes. In: Fedoroff, S., Juurlink, B.H.J., Doucette, R. (eds) Biology and Pathology of Astrocyte-Neuron Interactions. Altschul Symposia Series, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9486-1_6

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  • DOI: https://doi.org/10.1007/978-1-4757-9486-1_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9488-5

  • Online ISBN: 978-1-4757-9486-1

  • eBook Packages: Springer Book Archive

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