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Astroglial Response to Liver Failure

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Book cover Biology and Pathology of Astrocyte-Neuron Interactions

Part of the book series: Altschul Symposia Series ((ALSS,volume 2))

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Abstract

The brain is highly dependent on the integrity of other organs for its own function. Organ failure leads to neurological abnormalities often referred to as metabolic encephalopathies. While these encephalopathies are often reversible, permanent changes occur especially when the process has been severe or prolonged. Our laboratory has been particularly interested in the effect of liver failure on the nervous system, a condition referred to as hepatic encephalopathy (HE). It is a disorder in which astroglial changes dominate the histopathology. We have been working on the premise that this disorder may be a primary disorder of astrocytes and that the neuronal dysfunction results from a glial defect. We also believe that a better understanding of this disorder will yield insights into the function of astrocytes and into the CNS consequences of dysfunction of these cells. In this article, I will review recent progress concerning the role of astrocytes in HE especially as it deals with astroglial swelling.

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  1. Laboratory of Neuropathology Veterans Administration Medical Center and Department of Pathology, University of Miami/Jackson Memorial Hospital, Miami, FL, 33101, USA

    M. D. Norenberg

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  1. University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Sergey Fedoroff , Bernhard H. J. Juurlink  & Ronald Doucette ,  & 

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Norenberg, M.D. (1993). Astroglial Response to Liver Failure. In: Fedoroff, S., Juurlink, B.H.J., Doucette, R. (eds) Biology and Pathology of Astrocyte-Neuron Interactions. Altschul Symposia Series, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9486-1_35

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